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Piperazine

Piperazine Suppliers list
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
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Products Intro: Product Name:Piperazine
CAS:110-85-0
Purity:99.9% Package:1KG;7USD
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:Piperazine
CAS:110-85-0
Purity:98%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: CAS:110-85-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:1,4-Diazacyclohexane
CAS:110-85-0
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Email: bruce@xrdchem.cn
Products Intro: Product Name:Piperazine
CAS:110-85-0
Purity:99% Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Remarks:needle-like white or colorless crystals

Lastest Price from Piperazine manufacturers

  • Piperazine
  • US $23.00 / KG
  • 2018-07-25
  • CAS:110-85-0
  • Min. Order: 50KG
  • Purity: 99%
  • Supply Ability: 20T
Piperazine Chemical Properties
Melting point 109-112 °C(lit.)
Boiling point 146 °C
density 1,1 g/cm3
vapor pressure 0.8 mm Hg ( 20 °C)
FEMA 4250 | PIPERAZINE
refractive index 1.4460
Fp 65 °C
storage temp. Store in dark!
solubility H2O: 0.1 M at 20 °C, clear, colorless
pka9.83(at 23℃)
form Crystalline Flakes
color White to slightly yellow
PH11.0-12.5 (25℃, 0.1M in H2O)
explosive limit14%
Water Solubility 150 g/L (20 ºC)
Sensitive Air Sensitive & Hygroscopic
λmaxλ: 260 nm Amax: 0.035
λ: 280 nm Amax: 0.010
Merck 14,7464
BRN 102555
Stability:Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
InChIKeyGLUUGHFHXGJENI-UHFFFAOYSA-N
CAS DataBase Reference110-85-0(CAS DataBase Reference)
NIST Chemistry ReferencePiperazine(110-85-0)
EPA Substance Registry SystemPiperazine(110-85-0)
Safety Information
Hazard Codes C,Xn
Risk Statements 34-42/43-52/53-62-52-63
Safety Statements 22-26-36/37/39-45-61
RIDADR UN 2579 8/PG 3
WGK Germany 1
RTECS TK7800000
3-8-23
Hazard Note Harmful/Corrosive
TSCA Yes
HS Code 2933 59 95
HazardClass 8
PackingGroup III
Hazardous Substances Data110-85-0(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 2600 mg/kg LD50 dermal Rabbit 8300 mg/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Piperazine Usage And Synthesis
Important pharmaceutical intermediatesPiperazine is an important pharmaceutical intermediate, is mainly used for the production of anthelmintic piperazine phosphate, piperazine citrate and fluphenazine, strong pain, rifampicin, adipic acid piperazine, piperazine guanidine methyl tetracycline, quinoline piperazine phosphate, piperazine thiazole nitrate, enoxacin, hydroxyzine hydrochloride, trifluoperazine, diethylcarbamazine citrate, cinnarizine, flunarizine, decloxizine strong carbamazepine, prednisolone sodium phosphate, dexamethasone sodium phosphate, PPA, norfloxacin, ciprofloxacin, easy to cough piperazine, a piperazine Lee vancomycin, trimethoprim-triazine and other drugs. It is Also used for the production of surfactants products such as wetting agents, emulsifying agents,and dispersing agents ,and the production of plastic additives such as antioxidants, preservatives, stabilizers and rubber additives. It is derived from Dichloroethane by alcohol solution of ammonia.
The structural formula of piperazine
Figure 1 The structural formula of piperazine.
Pharmacology and mechanism of actionPiperazine is a heterocyclic organic base widely used as an anthelminthic. It was originally developed for the treatment of gout. Its first successful use in helminthiasis was reported by Mouriquand et al. in 1951 [1]. Presently the drug is used in the treatment of infections caused by Ascaris lumbricoides and Enterobius vermicularis.
The drug causes flaccid paralysis in susceptible worms and the parasites lose their attachment to the intestinal wall, and are swept away by the normal bowel peristalsis. The biochemical mechanism behind this action is uncertain. Piperazine causes hyperpolarization of the Ascaris muscle rendering it unresponsive to acetylcholine [2].
IndicationsTreatment of infections due to Ascaris lumbricoides and Enterobius vermicularis. When cost and availability are not a consideration, safer and more effective drugs such as mebendazole or albendazole should be used instead.
Side effectsSide effects commonly encountered with the recommended doses of piperazine are nausea, vomiting, abdominal cramps and diarrhoea which are usually mild and self-limiting. Although absolute incidence is unknown, severe side effects reported in the literature are rare. They can be classified into:
1. Allergic reactions such as urticaria, exantema, hypersensitivity, lacrimation, rhinorrea, productive cough, and bronchospasm[3,4].
2. Neuro-psychological reactions[5-11]:
(a) cerebral type such as vertigo, dizziness, tremor, incoordination, ataxia and hypotonia with EEG changes;
(b) psychic type such as depersonalization, hallucination and paranoic reactions;
(c) miscellaneous such as headache, visual disturbances, somnolence, coma and an increase in the number of petit mal attacks.
Neuro-psychological reactions are rare. Most cases reported concern children with pre disposing factors like neurological symptoms, renal diseases or those who have been treated with high doses of piperazine.
One case of haemolytic anaemia in a patient with G6PD deficiency [12], and one case of toxic hepatitis[13] have also been reported. However, no causal relationships can be established from these cases.
Nitrosation of piperazine to the potential carcinogen N-mononitrosopiperazine in the stomach of patients treated with normal therapeutic doses has been reported[14]. However, carcinogenicity related to the use of piperazine has not been reported despite the use of the drug over many years. In any case, this is unlikely to have any clinical implications with the short treatment period of nematodes.
Contraindications and precautionsPiperazine should not be given to patients with hypersensitivity or with neurological diseases,especially epileptic patients.
InteractionsIn rats and mice, piperazine 1–5 g/kg subcutaneously, potentiates the side effects of chlorpromazine [15]. However, this is unlikely to have any clinical significance. Piperazine is antagonistic to pyrantel, bephenium and levamisole , but no potential clinical interactions have been reported.
PreparationsSeveral preparations, apart from the one mentioned below, containing various piperazine salts are available.
• Antepar® (Wellcome). Oral suspension 150 mg piperazine hexahydrate/ml. Tablets 500 mg piperazine hexahydrate.
Acute oral toxicityrat LD50: 1900 mg/kg; Oral-Mouse LD50: 600 mg/kg
Data Skin irritationrabbit 500 mg Mild; Eyes-rabbit 0.25 mg/24 hours of severe
References1. Mouriquand G, Roman E, Coisnard J (1951). Essai de traitement de l’oxyurose par la piperazine. J Méd Lyon, 32, 189–195.
2. del Castillo J, De Mello WC, Morales T (1964). Mechanism of the paralysing action of piperazine on Ascaris muscle. Br J Pharmacol, 22, 463–477.
3. Macmillan AL (1973). Generalized pustular drug rash. Dermatologia, 146, 285–291.
4. McCullagh SF (1968). Allergenicity of piperazine: a study in environmental aetiology. Br J Ind Med, 25, 319–325.
5. Belloni C, Rizzoni G (1967). Neurotoxic side-effects of piperazine. Lancet, ii, 369.
6. Berger JR, Globus M, Melamed E (1979). Acute transitory cerebellar dysfunction associated with piperazine adipate. Arch Neurol, 36, 180–181.
7. Bomb RS, Bedi HK (1976). Neurotoxic side-effects of piperazine. Trans R Soc Trop Med Hyg, 70, 358.
8. Gupta SR (1976). Piperazine neurotoxicity and psychological reaction. J Ind Med Ass, 66, 33–34.
9. Parsons AC (1971). Piperazine neurotoxicity. ‘Worm wobble’. BMJ, 4, 790–792.
10. Vallat JN, Vallat JM, Texier J, Léger J (1972). Les signes neurologiques d’intoxication par la piperazine. Bordeaux Médicale, 5, 394–400.
11. Nickey LN (1966). Possible precipitation of petit mal seizures with piperazine citrate. J Am Med Ass, 195, 193–194.
12. Buchanan N, Cassel R, Jenkins T (1971). G-6-PD deficiency and piperazine. BMJ, 2, 110.
13. Hamlyn AN, Morris JS, Sarkany I, Sherlock S (1976). Piperazine hepatitis. Gastroenterology, 70, 1144–1147.
14. Bellander T, sterdahl B-G, Hagmar L (1985). Formation of N-mononitrosopiperazine in the stomach and its excretion in the urine after oral intake of piperazine. Toxicol Appl Pharmacol, 80, 193–198.
15. Sturman G (1973). Interaction between piperazine and chlorpromazine. Br J Pharmacol, 50, 153–155.
Flammability and hazardous characteristicsCombustible; decomposition of toxic nitric oxide gas in case of thermal
Storage characteristicsTreasury ventilation low-temperature drying; and stored separately from acid
Extinguishing agentWater spray, dry powder, carbon dioxide, alcohol-resistant foam
Professional standardsTWA 1 mg/m³; STEL 5 mg/m
Chemical PropertiesPiperazine is white to cream-colored needles or powder. Characteristic ammonia-like odor. Combustible solids that do not easily ignite.
UsesLabelled Piperazine
Useskeratolytic, antiseborheic
DefinitionChEBI: An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.
Brand namePincets (Marion Merrell Dow); Pinsirup (Marion Merrell Dow).
General DescriptionNeedle-like white or colorless crystals. Shipped as a solid or suspended in a liquid medium. Very corrosive to skin, eyes and mucous membranes. Solid turns dark when exposed to light. Flash point 190°F. Used as a corrosion inhibitor and as an insecticide.
Air & Water ReactionsFlammable. Absorbs water and carbon dioxide from air. Soluble in water.
Reactivity Profile1,4-Diazacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Absorbs carbon dioxide from the air, which can cause dry crystals to seem to melt. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. 1,4-Diazacyclohexane is sensitive to light; 1,4-Diazacyclohexane absorbs water and carbon dioxide from air. 1,4-Diazacyclohexane may be corrosive to aluminum, magnesium and zinc. .
Health HazardTOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire HazardCombustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Pharmaceutical ApplicationsA synthetic chemical, most commonly formulated as the citrate, but also available as the adipate, edetate calcium and tartrate salts.
Contact allergensPiperazine is contained in pyrazinobutazone, an equimolar salt of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory workers, in nurses, and in veterinarians.
PharmacokineticsActivity against intestinal worms requires that a substantial amount remains in the gut. However, after oral administration a variable amount is rapidly absorbed from the small intestine and subsequently excreted in the urine. Its half-life is extremely variable.
Clinical UseAscariasis
Pinworm
Side effectsSome people develop hypersensitivity, requiring cessation of treatment. Transient, mild gastrointestinal or neurological symptoms may occur.
Safety ProfileModerately toxic by ingestion, skin contact, intravenous, and subcutaneous routes. Mildly toxic by inhalation. A skin and severe eye irritant. Excessive absorption can cause urticaria, vomiting, diarrhea, blurred vision, and weakness. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. Explodes on contact with dicyanofurazan. To fight fire, use alcohol foam, mist, dry chemical, water spray. When heated to decomposition it emits highly toxic fumes of NOx.
Potential Exposure(Piperazine): Primary irritant (w/o allergic reaction),
First aidIf this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water, or milk. Do not induce vomiting. Medical observation is recommended for 2448 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
ShippingUN2579 Piperazine, Hazard class: 8; Labels: 8-Corrosive material.
Purification MethodsPiperazine crystallises from EtOH or anhydrous *benzene and is dried at 0.01mm. It can be sublimed under vacuum and purified by zone melting. The hydrochloride has m 172-174o (from EtOH), and the dihydrochloride crystallises from aqueous EtOH and has m 318-320o (dec, sublimes at 295-315o). The picrate has m ~200o, and the picrolonate crystallises from dimethylformamide ( m 259-261o). [Beilstein 23 H 4, 23 I 4, 23 II 3, 23 III/IV 15, 23/1 V 30.]
IncompatibilitiesAqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.
Piperazine Preparation Products And Raw materials
Raw materialsAmmonium hydroxide-->Ethanolamine-->2-Chloroethanol-->Paraffin wax-->PIPERAZINE HEXAHYDRATE-->PIPERAZINE DIHYDROCHLORIDE-->ETHANOLAMINE HYDROCHLORIDE
Preparation Products1-(3-METHOXYPROPYL)-PIPERAZINE-->1-(3-PHENYLPROPYL)PIPERAZINE-->1-Boc-piperazine-->Sarafloxacin-->TRIFORINE-->1-[5-(Trifluoromethyl)pyridin-2-yl]piperazine-->Terazosin-->5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride-->4-Amino-3-hydrazino-1,2,4-triazol-5-thiol-->2-PIPERAZIN-1-YLISONICOTINIC ACID-->1-[3-(DIMETHYLAMINO)PROPYL]PIPERAZINE-->1,4-Bis(3-aminopropyl)piperazine-->2-PIPERAZIN-1-YL-ACETAMIDEHYDROCHLORIDE-->clopenthixol -->Flunarizine dihydrochloride-->1-(CYCLOHEXYLCARBONYL)PIPERAZINE 97-->1-BOC-PIPERAZINE-->1-(2-CHLORO-6-FLUOROBENZYL)PIPERAZINE-->4-Piperazinobenzonitrile-->1-Butylpiperazine-->1-(4-PYRIDYLMETHYL)PIPERAZINE-->Amoxapine-->1-(1-Methyl-4-piperidinyl)piperazine-->1-(3-Nitorpyridin-2-yl)piperazine-->Cefbuperazone-->VESNARINONE-->BENZYL 1-PIPERAZINECARBOXYLATE-->1-(3-CHLOROBENZYL)PIPERAZINE-->1-(2-CHLOROBENZYL)PIPERAZINE-->TRANS-1-CINNAMYLPIPERAZINE-->3-PIPERAZIN-1-YL-PROPIONITRILE-->N,N-DIMETHYL-2-PIPERAZIN-1-YL-ACETAMIDE-->1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE-->1,4-DIFORMYLPIPERAZINE-->PIPERAZINE-1-CARBOXYLIC ACID DIMETHYLAMIDE-->1-(3-METHYLPYRIDIN-2-YL)PIPERAZINE-->PIPERAZINE CITRATE-->4-(3-CHLOROPROPYL)-1-PIPERAZINE ETHANOL-->1-[2-(4-PYRIDYL)ETHYL]PIPERAZINE-->Piperaquine phosphate
Tag:Piperazine(110-85-0) Related Product Information
1-[2-(2-O-TOLYL-IMIDAZOL-4-YL)-ETHYL]-PIPERAZINE 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-4-(2,3-DIHYDRO-1H-INDEN-2-YL)-PIPERAZINE 1,2,2-TRIMETHYL-3-(4-METHYL-PIPERAZINE-1-CARBONYL)-CYCLOPENTANECARBOXYLIC ACID 11,11'-(PIPERAZINE-1,4-DIYL)-BIS-8-CHLORO-5H-DIBENZE[B,E][1,4]-DIAZEPINE 1-[2-(2-METHOXY-PHENOXY)-ETHYL]-PIPERAZINE 1-[2-(2-PROPYL-1H-IMIDAZOL-4-YL)-ETHYL]-PIPERAZINE 1-[(2,3,5,6-TETRAMETHYLPHENYL)SULFONYL]PIPERAZINE HYDROCHLORIDE 1-[2-(2-PHENETHYL-IMIDAZOL-4-YL)-ETHYL]-PIPERAZINE 1-(2,3-DICHLOROPHENYL)PIPERAZINE HCL 1-[(2,3,4-TRIFLUOROPHENYL)SULFONYL]PIPERAZINE 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLCARBONYL)-4-(2-FLUOROPHENYL)PIPERAZINE 1-[2-(2-ISOPROPYL-5-METHYL-PHENOXY)-ETHYL]-PIPERAZINE 1-(2,3-DICHLOROPHENYL)PIPERAZINE,1-(2,3-DICHLOROPHENYL)PIPERAZINE HCL 1-[2-(2-SEC-BUTYL-IMIDAZOL-4-YL)-ETHYL]-PIPERAZINE Piperazine 1-Methylpiperazine 1-(2-Methoxyphenyl)piperazine 2-Methylpiperazine