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Heptafluorobutyric acid

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Products Intro: Product Name:Heptafluorobutyric acid
CAS:375-22-4
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:Heptafluorobutyric acid
CAS:375-22-4
Purity:99% Package:100g ;1KG ;5KG 25KG
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Products Intro: Product Name:Heptafluorobutyric acid
CAS:375-22-4
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Products Intro: Product Name:Heptafluorobutyric acid
CAS:375-22-4
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Products Intro: Product Name:Heptafluorobutyric acid
CAS:375-22-4
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Heptafluorobutyric acid Basic information
Product Name:Heptafluorobutyric acid
Synonyms:TIMTEC-BB SBB008777;N-HEPTAFLUOROBUTYRIC ACID;PERFLUOROBUTBUTYRIC ACID;RARECHEM AL BO 0423;HEPTAFLUOROBUTYRC ACID;HEPTAFLUOROBUTYRIC ACID, FOR ION CHROMATOGRAPHY;HEPTAFLUOROBUTYRIC ACID FOR PROTEIN SEQ.;Heptafluorobutyric acid Solution
CAS:375-22-4
MF:C4HF7O2
MW:214.04
EINECS:206-786-3
Product Categories:HPLC and LCMS Mobile Phase Additive;GC Derivatizing Reagents;Analytical Chemistry;Ion-Pair Reagents for HPLC;LC/MS Ion-Pair Reagents for Basic Samples;Acylation (GC Derivatizing Reagents);Pharmaceutical Intermediates
Mol File:375-22-4.mol
Heptafluorobutyric acid Structure
Heptafluorobutyric acid Chemical Properties
Melting point -17.5 °C
Boiling point 120 °C755 mm Hg(lit.)
density 1.645 g/mL at 25 °C(lit.)
vapor density 7 (vs air)
vapor pressure ~10 mm Hg ( 25 °C)
refractive index n20/D 1.3(lit.)
Fp 120-121°C
storage temp. Store below +30°C.
solubility Chloroform: soluble; Methanol: soluble
form Powder
pkapK1:0.17 (25°C)
Specific Gravityapproximate 1.6
color Clear colorless to faint yellow
PH1 (H2O, 20℃)
Water Solubility miscible
Sensitive Light Sensitive
BRN 1426882
InChIKeyYPJUNDFVDDCYIH-UHFFFAOYSA-N
CAS DataBase Reference375-22-4(CAS DataBase Reference)
NIST Chemistry ReferenceButanoic acid, heptafluoro-(375-22-4)
EPA Substance Registry SystemHeptafluorobutyric acid (375-22-4)
Safety Information
Hazard Codes C
Risk Statements 34-35
Safety Statements 26-36/37/39-45
RIDADR UN 3265 8/PG 2
WGK Germany 3
RTECS ET4025000
3-8-10
Hazard Note Corrosive
TSCA T
HazardClass 8
PackingGroup II
HS Code 29159000
MSDS Information
ProviderLanguage
Heptafluorobutyric acid English
SigmaAldrich English
ACROS English
ALFA English
Heptafluorobutyric acid Usage And Synthesis
Chemical PropertiesClear colorless to faintly yellow liquid
UsesPerfluorobutyric acid was used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It was used as ion pairing reagent in preparative and analytical reserved phase HPLC of underivatised peptides.
UsesHeptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.
UsesHeptafluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides. It is used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It is an effective additive for zinc electrodeposition.
DefinitionChEBI: A monocarboxylic acid that is perfluorinated butyric acid.
General DescriptionPerfluorobutyric acid is an effective additive for zinc electrodeposition.
HazardIrritant to tissue.
Purification MethodsFractionally distil the acid twice in an Oldershaw column (p 10) with an automatic vapour-dividing head, the first distillation being in the presence of conc H2SO4 as a drying agent. (Take care with the hot acid.) [Beilstein 2 IV 810.]
Tag:Heptafluorobutyric acid(375-22-4) Related Product Information
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