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Lithium amide

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Products Intro: CAS:7782-89-0
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Lastest Price from Lithium amide manufacturers

  • Lithium amide
  • US $1.00 / KG
  • 2020-01-13
  • CAS:7882-89-0
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100KG
  • Lithium amide
  • US $1.00 / KG
  • 2019-07-06
  • CAS:7782-89-0
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Lithium amide Basic information
Preparation Reactions
Product Name:Lithium amide
Synonyms:Lithium amide (Li(NH2));Lithiumamid;lithium azanide;Aminolithium;Lithioamine;Litium amide;LITHIUM AMIDE FOR SYNTHESIS;lithamide
Product Categories:metal amide;Alternative Energy;Amides;Chemical Synthesis;Inorganic Bases;Materials for Hydrogen Storage;Inorganics;Alternative Energy;AmidesChemical Synthesis;Inorganic Bases;Materials for Hydrogen Storage;Organic Bases;Materials Science;Synthetic Reagents;Synthetic Reagents
Mol File:7782-89-0.mol
Lithium amide Structure
Lithium amide Chemical Properties
Melting point 373 °C
Boiling point 430 °C
density 1.178 g/mL at 25 °C(lit.)
refractive index 1.178g/mL
storage temp. water-free area
solubility Slightly soluble in ethanol and liquid ammonia. Insoluble in anhydrous ether, benzene and toluene.
form Powder
Specific Gravity1.178
color off-white
Water Solubility reacts
Sensitive Air & Moisture Sensitive
Merck 14,5522
CAS DataBase Reference7782-89-0(CAS DataBase Reference)
EPA Substance Registry SystemLithium amide (7782-89-0)
Safety Information
Hazard Codes F,C
Risk Statements 14/15-29-34-20/21/22-15-14-11
Safety Statements 26-36/37/39-43-45-7/8-43B-16-3/7/9
RIDADR UN 1390 4.3/PG 2
WGK Germany 2
RTECS OJ5590000
HazardClass 4.3
PackingGroup II
HS Code 28530090
Hazardous Substances Data7782-89-0(Hazardous Substances Data)
MSDS Information
ACROS English
SigmaAldrich English
ALFA English
Lithium amide Usage And Synthesis
PreparationLithium amide is obtained by dissolution of lithium metal in liquid ammonia. The reaction is slow, but may be catalyzed by cobalt nitrate:
2Li + 2NH3 → 2LiNH2 + H2
It also is obtained by passing gaseous ammonia over lithium hydride:
LiH + NH3 → LiNH2 + H2
ReactionsLithium amide decomposes to imide when heated above 400°C: 2LiNH2 → Li2NH + NH3
It is used in several organic syntheses. Some of these synthetic reactions are based on the mechanism that the terminal alkynes react with the stronger base, the anion, forming the weaker conjugate base:

It converts vic dibromide to bromoalkene and then alkyne:

Ketones can be converted into alkynes:
Chemical Propertieswhite to grey fine powder
Physical propertiesColorless needles; tetragonal structure; density 1.178 g/cm3 at 17.5°C; melts around 375°C; starts to decompose at 320°C; decomposes at 400°C; soluble in cold water; decomposes in hot water; slightly soluble in ethanol and liquid ammonia; insoluble in benzene and ether.
UsesReagent for synthesis of: Antiinflamatory and preoresolving protectin D11 Chemotype dipeptidyl peptidase IV inhibitors2 Sterically congested triarylamines3 Dyes displaying large Stokes shifts4 GM1 ganglioside derivatives5Reagent for cross-coupling of aryl chlorides and amines6
UsesIn Claisen condensations, alkylation of nitriles and ketones, synthesis of ethynyl Compounds, acetylenic carbinols.
PreparationLithium amide, LiNH2 , may be considered the ammonia analogue of lithium hydroxide in the water system. Lithium amide may be prepared from lithium hydride or lithium metal and ammonia. Industrial preparations use lithium hydride as a starting material.
The reaction of lithium metal in a stream of ammonia gas at about 400°C may be used successfully as a preparative method. Lithium may also be reacted with liquid ammonia in the presence of an iron compound as a catalyst.
Since amide ion is the strongest base which can exist in ammonia, lithium amide is a very strong base. The compound has a low solubility in liquid ammonia. Lithium amide is hydrolyzed by water to yield lithium hydroxide and ammonia. It is readily oxidized. For example, the substance may be oxidized with dinitrogen oxide to yield lithium azide. Amides of the alkali metals in general must be guarded against air oxidation to prevent the formation of potentially explosive substances.
General DescriptionWhite crystalline powder with an odor of ammonia. Denser than water.
Reactivity ProfilePowdered Lithium amide is highly reactive. A strong base. Reacts to release toxic ammonia gas with water. Forms explosive peroxide on storage.
Health HazardHighly toxic: contact with water produces toxic gas, may be fatal if inhaled. Inhalation or contact with vapors, substance or decomposition products may cause severe injury or death. May produce corrosive solutions on contact with water. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.
Fire HazardProduce flammable and toxic gases on contact with water. May ignite on contact with water or moist air. Some react vigorously or explosively on contact with water. May be ignited by heat, sparks or flames. May re-ignite after fire is extinguished. Some are transported in highly flammable liquids. Containers may explode when heated. Runoff may create fire or explosion hazard.
Safety ProfileA powerful irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat or flame. Ammonia is liberated and lithmm hydroxide is formed when this compound is exposed to moisture. Reacts violently with water or steam to produce toxic and flammable vapors. Vigorous reaction with oxilzing materials. Exothermic reaction with acid or acid fumes. When heated to decomposition it emits very toxic fumes of LiO, NH3, and NO,. Used in synthesis of drugs, vitamins, steroids, and other organics. See also LITHIUM COMPOUNDS, AMIDES, AMMONIA, and LITHIUM HYDROXIDE.
Purification MethodsPurify it by heating at 400o while NH3 is passed over it in the upper of two crucibles (the upper crucible is perforated). The LiNH2 will drip into the lower crucible through the holes in the upper crucible. The product is cooled in a stream of NH3. Protect it from air and moisture, store it under N2 in a clear glass bottle sealed with paraffin. Store it in small quantities so that all the material is used once the bottle is opened. If the colour of the amide is yellow, it should be destroyed as it is likely to have oxidised and to EXPLODE. On heating above 450o it is decomposed to Li2NH, which is stable up to 750-800o. [Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 463 1963, Greenlee & Henne Inorg Synth II 135 1953.]
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