| | propylhexedrine Basic information |
| Product Name: | propylhexedrine | | Synonyms: | propylhexedrine;Einecs 222-741-0;Propilesedrina;Propilesedrina [dcit];Propilhexedrina;Propilhexedrina [inn-spanish];Propylhexedrine, DL-;propylhexedrine USP/EP/BP | | CAS: | 3595-11-7 | | MF: | C10H21N | | MW: | 155.28044 | | EINECS: | 222-741-0 | | Product Categories: | | | Mol File: | 3595-11-7.mol |  |
| | propylhexedrine Chemical Properties |
| Boiling point | bp760 205°; bp20 92-93° | | density | d425 0.8501 | | refractive index | nD20 1.4600 | | pka | pKa 10.52(H2O,t =25±0.2,I≤0.001) (Uncertain) |
| | propylhexedrine Usage And Synthesis |
| Uses | Adrenergic (vasoconstrictor). | | Definition | ChEBI: Propylhexedrine is a secondary amino compound. | | Brand name | Dristan Inhaler (Whitehall-Robins);Benzedrex;Chp-depot;Cyclexedrine;Eggobesin;Eventin. | | World Health Organization (WHO) | Propylhexedrine, a sympathomimetic amine, has been widely
available since 1949 in over-the-counter inhalants for nasal decongestion and in
oral anorexic preparations. As dependence can occur and because abuse has been
reported, propylhexedrine was subjected in 1986 to control under Schedule IV of
the 1971 Convention on Psychotropic Substances.
(Reference: (WHTAC2) 2nd Report of the WHO Expert Committee on Drug
Dependence (IV), 729, , 1985) | | Synthesis Reference(s) | Journal of the American Chemical Society, 80, p. 5270, 1958 DOI: 10.1021/ja01552a063 | | General Description | Propylhexedrine is another analog ofamphetamine in which the aromatic ring has been replacedwith a cyclohexane ring. This drug produces vasoconstrictionand a decongestant effect on the nasal membranes, butit has only about one half the pressor effect of amphetamineand produces decidedly fewer effects on the CNS. Its majoruse is for a local vasoconstrictive effect on nasal mucosa inthe symptomatic relief of nasal congestion caused by thecommon cold, allergic rhinitis, or sinusitis. | | Synthesis | Propylhexedrine is prepared by catalytic hydrogenation
of (±)- or (-)-ephedrine in a strong
mineral acid .
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| | propylhexedrine Preparation Products And Raw materials |
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