Company Name: |
Block Chemical Technology (Shanghai) Co., LTD
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Tel: |
021-20432219 13918097649 |
Email: |
li_jinfei@acblock-lab.com |
Products Intro: |
Product Name:2-(1-hydroxycyclohexyl)butanoic acid CAS:512-16-3 Purity:95% by NMR Package:1G,5G Remarks:R&D in stock EN
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:Cyclobutyrol CAS:512-16-3 Purity:0 Package:1mg
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| cyclobutyrol Basic information |
Product Name: | cyclobutyrol | Synonyms: | cyclobutyrol;Bilimix;Epadomus;Epatodin;Hebucol;Hebulina;Tribil;JL 130 | CAS: | 512-16-3 | MF: | C10H18O3 | MW: | 186.249 | EINECS: | 2081385 | Product Categories: | | Mol File: | 512-16-3.mol | |
| cyclobutyrol Chemical Properties |
Melting point | 81-82° | Boiling point | bp24 164°; bp16 167-170° | density | d418.8 1.0010 | refractive index | nD18.8 1.4680 (Kon, Naravanan, loc. cit.) | pka | 4.69±0.10(Predicted) | EPA Substance Registry System | Cyclobutyrol (512-16-3) |
Toxicity | LD50 oral in rat: 4820mg/kg |
| cyclobutyrol Usage And Synthesis |
Originator | Hebucol,Logeais,France,1957 | Definition | ChEBI: A hydroxy monocarboxylic acid in which the hydroxy group is geminal to a 1-carboxypropyl group on a cyclohexane ring. | Manufacturing Process | Into a balloon flask with two lateral necks furnished with an efficient
mechanical agitator and protected from moisture by a calcium chloride guard,
there are introduced 12 g (0.185 mol) of pure powdered zinc and 20 ml of a
solution of 16.6 g (0.17 mol) of anhydrous cyclohexanone and 31.5 g (0.16
mol) of ethyl α-bromobutyrate in 25 ml of anhydrous benzene. With vigorous
stirring in a manner to put the zinc into suspension, the balloon flask is
gradually heated in an oil bath to 100°C to 105°C. After a few minutes, a
reaction starts, causing violent boiling which is maintained while adding the
balance of the reactants. Boiling is then continued for one hour. After cooling,
the reaction mixture is turned into a beaker containing 30 ml of sulfuric acid
to half (by volume) with ice. After agitation, the mixture is decanted into a
container for separation. The aqueous phase is reextracted with benzene. The
pooled benzene solutions are washed with dilute (10%) cold sulfuric acid, then
with cold sodium carbonate (5%) and then with ice water, and dried over
anhydrous sodium sulfate. The benzene is evaporated and the ester, which is
ethyl α(hydroxy-1-cyclohexyl) butyrate, is distilled off under reduced pressure.
The yield obtained was 17 to 19 g or 49% to 55%. The ester was saponified with baryta in aqueous methanol as follows: 21.5 g (0.1 mol) of the above ethyl ester is saponified by boiling under reflux
for 4 hours, while agitating, with 30 g (0.095 mol) of barium oxide hydrated
to 8H2O in 250 ml of a mixture of equal volumes of methanol and water. After
concentration to one-half its volume under reduced pressure and filtration, the
aqueous solution is washed with ether and then acidified at 0°C with 10%
hydrochloric acid. The acid liberated in oily form is extracted with ether. The
ether is washed with water, dried and evaporated. The yield is 75-80% (14-15
g of crude acid) which crystallizes spontaneously little by little. It can be
crystallized in a mixture of ether and petroleum ether (1:10) or, with better
yield, in light gasoline or oil (solubility of the pure acid ranges from 0.3% at
0°C to 100% at the boiling point). The yield of crystals is 75-80%. The
α(hydroxy-1-cyclohexyl) butyric acid thus obtained is a colorless crystalline
product with a melting point of 81°C to 82°C. | Therapeutic Function | Choleretic |
| cyclobutyrol Preparation Products And Raw materials |
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