| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
| Products Intro: |
Product Name:QD-394
CAS:2132411-21-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:QD-394
CAS:2132411-21-1
Purity:98% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:QD-394
CAS:2132411-21-1
Package:1mg/RMB 857;5mg/RMB 3970;10mg/RMB 7470
|
QD-394 manufacturers
- QD-394
-
- $123.00 / 1mg
-
2024-10-28
- CAS:2132411-21-1
- Min. Order:
- Purity:
- Supply Ability: 10g
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| Product Name: | QD-394 | | Synonyms: | QD-394;QD 394,QD394;5,8-Quinazolinedione, 6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-;6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5,8-quinazolinedione | | CAS: | 2132411-21-1 | | MF: | C19H19N5O2 | | MW: | 349.39 | | EINECS: | | | Product Categories: | | | Mol File: | 2132411-21-1.mol |  |
| | QD-394 Chemical Properties |
| Boiling point | 566.3±50.0 °C(Predicted) | | density | 1.368±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 1 mg/lm,DMSO: 5 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml,Ethanol: 1 mg/lm,PBS (pH 7.2): slightly soluble | | form | A crystalline solid | | pka | 7.92±0.42(Predicted) | | color | Brown to black |
| | QD-394 Usage And Synthesis |
| Uses | QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis[1]. | | Biological Activity | QD-394 is an inducer of reactive oxygen species (ROS) production.1 It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells. | | References | 1.Hu, S., Sechi, M., Singh, P.K., et al.A novel redox modulator induces a GPX4-mediated cell death that is dependent on iron and reactive oxygen speciesJ. Med. Chem.63(17)9838-9855(2020) |
| | QD-394 Preparation Products And Raw materials |
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