| Company Name: |
Nanjing Shizhou Biology Technology Co.,Ltd
|
| Tel: |
025-025-85560043 17301488900 |
| Email: |
info@synzest.com |
| Products Intro: |
Product Name:N-[2-(3,5-difluorophenyl)ethyl]-4-(2-fluoro-5-{[(2S)-
2-methylpiperazin-1-yl]methyl}phenyl)pyrimidin-2-
amine
CAS:859518-94-8
Purity:95% Package:1g；5g;10g
|
| Company Name: |
Nanjing Shizhou Biology Technology Co.,Ltd
|
| Tel: |
18351873721 |
| Email: |
helen.zhang@synzest.com |
| Products Intro: |
Product Name:N-[2-(3,5-difluorophenyl)ethyl]-4-(2-fluoro-5-{[(2S)-
2-methylpiperazin-1-yl]methyl}phenyl)pyrimidin-2-
amine
CAS:859518-94-8
Purity:95% Package:1g；5g;10g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:T0467
CAS:859518-94-8
Package:2mg/RMB 1820
|
| Company Name: |
https://hanhongsci.com/
|
| Tel: |
021-54306202 18917919676 |
| Email: |
info@hanhongsci.com |
| Products Intro: |
Product Name:2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]-
CAS:859518-94-8
Purity:99.37% Package:5mg;25mg;100mg;1g;5g
|
|
| | 2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- Basic information |
| | 2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- Chemical Properties |
| Boiling point | 570.2±60.0 °C(Predicted) | | density | 1.251±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 33.33 mg/mL (75.49 mM; Need ultrasonic) | | form | Solid | | pka | 9.14±0.40(Predicted) | | color | Off-white to light brown |
| | 2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- Usage And Synthesis |
| Uses | T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research[1]. | | Biological Activity | T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson’s disease and related disorders research[1].
T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells[1]. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells[1].T0467 does not show obvious toxicity in Drosophila at concentrations Drosophila larval muscles[1]. | | References | [1]. Kahori Shiba-Fukushima, et al. A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling. iScience. 2020 May 22;23(5):101048. |
| | 2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- Preparation Products And Raw materials |
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