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Fasudil hydrochloride

Fasudil hydrochloride Suppliers list
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Products Intro: Product Name:Fasudil hydrochloride
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Shanghai Payne Pharmaceutical Technology Co.Ltd
Tel: 021-58123769
Products Intro: Product Name:Fasudil hydrochloride
Purity:0.99 Package:5KG;1KG
Company Name: Frapp's ChemicalNFTZ Co., Ltd.
Tel: +86 (576) 8169-6106
Products Intro: Product Name:Fasudil hydrochloride
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Products Intro: Product Name:Fasudil hydrochloride
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:105628-07-7
Purity:0.99 Package:25KG,5KG;1KG;500G

Lastest Price from Fasudil hydrochloride manufacturers

  • Fasudil hydrochloride
  • US $0.00 / KG
  • 2020-10-27
  • CAS:105628-07-7
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Fasudil hydrochloride
  • US $0.00-0.00 / KG
  • 2020-05-12
  • CAS:105628-07-7
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 500 MT
  • Fasudil hydrochloride
  • US $1.00 / KG
  • 2019-07-06
  • CAS:105628-07-7
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Fasudil hydrochloride Basic information
Indications and Usage Mechanisms of Action Adverse reactions Warnings and Precautions
Product Name:Fasudil hydrochloride
Product Categories:Cardiovascular & Blood System Agents;Inhibitors;Inhibitor;API;APIs
Mol File:105628-07-7.mol
Fasudil hydrochloride Structure
Fasudil hydrochloride Chemical Properties
Melting point 220.5°; mp 219.3° (Shirotani)
solubility H2O: >200 mg/mL
form solid
color white
Water Solubility Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.
Merck 14,3942
CAS DataBase Reference105628-07-7(CAS DataBase Reference)
Safety Information
Risk Statements 22
Safety Statements 36-60
WGK Germany 3
RTECS HM4031166
HS Code 29339900
ToxicityLD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga)
MSDS Information
SigmaAldrich English
Fasudil hydrochloride Usage And Synthesis
Indications and UsageFasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.
Mechanisms of ActionFasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.
Adverse reactionsAdverse reactions after use can include intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, nasal bleeding, subcutaneous bleeding, and loss of consciousness, etc., as well as abnormal liver function. Low blood pressure, anemia, leukopenia, renal dysfunction, polyuria, rashes, and fever, etc. occur occasionally.
Warnings and PrecautionsPatients with intracranial hemorrhage or possibility thereof, or low blood pressure, should not use. Patients with diabetes mellitus, cerebral arterial sclerosis, severe disturbance of consciousness, subarachnoid hemorrhages with cerebrovascular disorders, and liver or kidney dysfunction, or those over 70 years old, pregnant, or children should use with caution. Breastfeeding women should stop while using the drug. Fasudil Hydrochloride can only be administered via intravenous drip.
DescriptionFasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed for the treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase C. In contrast to other calcium channel blockers, which regulate the influx of calcium ions through the cell membrane but not involved in the intracellular regulatory mechanism of the calcium, fasudil was suggested to have an intracellular mode of action in relaxing vascular smooth muscle. In patients with neurological deficits due to vasospasm, fasudil decreased the occurrence of angiographic severe and symptomatic vasospasm and cerebral infarction without decreasing systemic blood pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of cerebral vascular diseases and angina pectoris.
OriginatorAsahi Chemical (Japan)
Usesvasodilator, potent Rho-kinase inhibitor
Brand nameEril
Fasudil hydrochloride Preparation Products And Raw materials
Tag:Fasudil hydrochloride(105628-07-7) Related Product Information
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