| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Gut restricted-7;acid,Inhibitor,bile,Bacterial,orally,Nontoxic,GR7,Gut restricted 7,GR 7,Gut restricted7,gut,BSH,gut-restricted,inhibit,Gut restricted-7
CAS:2553218-46-3
Purity:99.27% Package:1 mg;1 mL;10 mg;100 mg;25 mg;5 mg;50 mg
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| | 26,27-Dinorcholestan-24-one, 25-fluoro-7-hydroxy-3-(sulfooxy)-, sodium salt (1:1), (3α,5β,7α)- Basic information |
| Product Name: | 26,27-Dinorcholestan-24-one, 25-fluoro-7-hydroxy-3-(sulfooxy)-, sodium salt (1:1), (3α,5β,7α)- | | Synonyms: | 26,27-Dinorcholestan-24-one, 25-fluoro-7-hydroxy-3-(sulfooxy)-, sodium salt (1:1), (3α,5β,7α)-;acid,Inhibitor,bile,Bacterial,orally,Nontoxic,GR7,Gut restricted 7,GR 7,Gut restricted7,gut,BSH,gut-restricted,inhibit,Gut restricted-7 | | CAS: | 2553218-46-3 | | MF: | C25H42FNaO6S | | MW: | 512.65 | | EINECS: | | | Product Categories: | | | Mol File: | 2553218-46-3.mol |  |
| | 26,27-Dinorcholestan-24-one, 25-fluoro-7-hydroxy-3-(sulfooxy)-, sodium salt (1:1), (3α,5β,7α)- Chemical Properties |
| storage temp. | 4°C, away from moisture |
| | 26,27-Dinorcholestan-24-one, 25-fluoro-7-hydroxy-3-(sulfooxy)-, sodium salt (1:1), (3α,5β,7α)- Usage And Synthesis |
| Biological Activity | Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice[1].
BSH Inhibitor Gut restricted-7 (GR-7) (60 μM) does not affect epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic. Gut restricted-7 also does not affect microbial biomass[1].
The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (GR-7) (w/w) for 1 d day or powdered chow alone. Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitortreated mice 8 h postdiet change. 20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected[1]. | | References | [1]. Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 Mar;16(3):318-326. |
| | 26,27-Dinorcholestan-24-one, 25-fluoro-7-hydroxy-3-(sulfooxy)-, sodium salt (1:1), (3α,5β,7α)- Preparation Products And Raw materials |
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