| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:MW108
CAS:1454658-89-9
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
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3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) manufacturers
- MW108
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- $1980.00 / 50mg
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2025-08-21
- CAS:1454658-89-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) Basic information |
| | 3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) Chemical Properties |
| | 3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) Usage And Synthesis |
| Description | MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor. It acts by ameliorating beta-amyloid induced synaptic and cognitive dysfunction and preventing early memory loss in Alzheimer's disease. | | Uses | MW108 (MW01-11-108SRM) hydrochloride is a selective and CNS-penetrant p38αMAPK inhibitor with a Ki of 114 nM. MW108 hydrochloride ameliorates beta-amyloid induced synaptic and cognitive dysfunction[1]. | | IC 50 | p38α MAPK: 114 nM (Ki) | | References | [1] D Martin Watterson, et al. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. PLoS One. 2013 Jun 26;8(6):e66226. DOI:10.1371/journal.pone.0066226 |
| | 3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) Preparation Products And Raw materials |
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