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| | 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Basic information |
| | 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Chemical Properties |
| Melting point | 320° (dec) | | density | 1.527 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in DMSO | | form | solid | | pka | 7.44±0.10(Predicted) | | color | Yellow | | λmax | 284nm(MeOH)(lit.) | | Merck | 14,3584 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Usage And Synthesis |
| Description | Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug. | | Uses | Potent inactivator of Dihydropyrimidine dehydrogenase (DPD). | | Definition | ChEBI: Eniluracil is a pyrimidone. | | References | 1) Porter?et al. (1992),?Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem.,?267?5236
2) Baccalnari?et al. (1993),?5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA,?90?11064
3) Schilsky and Kindler (2000)?Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs,?9?1635 |
| | 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Preparation Products And Raw materials |
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