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Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1)

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Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1) Suppliers list
Company Name: Aladdin Scientific
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Products Intro: Product Name:DYRKs-IN-1 hydrochloride
CAS:1386980-55-7
Purity:99% Package:$750.9/5mg;$1200.9/10mg;Bulk package Remarks:99%
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
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Email: vip@med-life.cn
Products Intro: Product Name:DYRKs-IN-1 hydrochloride
CAS:1386980-55-7
Purity:>=99% Package:100mg;50mg;5mg;10mg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:DYRKs-IN-1 hydrochloride
CAS:1386980-55-7
Package:50mg/RMB 26900;25mg/RMB 19800;100mg/RMB 35500
Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1) Basic information
Product Name:Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1)
Synonyms:Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1);DYRKs-IN-1 hydrochloride
CAS:1386980-55-7
MF:C30H31Cl2N7O4
MW:624.52
EINECS:
Product Categories:
Mol File:1386980-55-7.mol
Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1) Structure
Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1) Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 20.83 mg/mL (33.35 mM; ultrasonic and warming and heat to 60°C)
form Solid
color Yellow to brown
Safety Information
MSDS Information
Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1) Usage And Synthesis
UsesDYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity[1][2].
Biological ActivityDYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity[1][2]. DYRKs-IN-1 hydrochloride (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[1]. DYRKs-IN-1 hydrochloride (Example 183) is a potent DYRKs inhibitor[2].
IC 50DYRK1A: 5 nM (IC50); DYRK1B: 8 nM (IC50)
References[1]. Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5. [2]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1.
Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1) Preparation Products And Raw materials
Tag:Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1)(1386980-55-7) Related Product Information
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