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Lisinopril

Lisinopril Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:76547-98-3
CAS:76547-98-3
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Guangzhou PI PI Biotech Inc
Tel: ; +8618371201331;+8618371201331
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Products Intro: Product Name:Lisinopril
CAS:76547-98-3
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:(S)-1-[(S)-6-AMINO-2-((S)-1-CARBOXY-3-PHENYL-PROPYLAMINO)-HEXANOYL]-PYRROLIDINE-2-CARBOXYLIC ACID
Company Name: career henan chemical co
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Products Intro: Product Name:Lisinopril
CAS:76547-98-3
Purity:99% Package:1kg;2USD
Company Name: Chongqing Chemdad Co., Ltd
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Products Intro: Product Name:Lisinopril
CAS:76547-98-3
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: 15319487004
Email: 1015@dideu.com
Products Intro: Product Name:Lisinopril
CAS:76547-98-3
Purity:99% Package:100G,1KG,5KG,10KG,25KG

Lisinopril manufacturers

  • Lisinopril USP/EP/BP
  • $1.10 / g
  • 2021-08-11
  • CAS:76547-98-3
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
  • Lisinopril
  • $15.00-10.00 / KG
  • 2021-07-13
  • CAS:76547-98-3
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Lisinopril
  • $15.00-10.00 / KG
  • 2021-07-10
  • CAS:76547-98-3
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Lisinopril Basic information
Product Name:Lisinopril
Synonyms:(S)-1-[(S)-6-AMINO-2-((S)-1-CARBOXY-3-PHENYL-PROPYLAMINO)-HEXANOYL]-PYRROLIDINE-2-CARBOXYLIC ACID;TENSOPRIL;VIVATEC;ZESTRIL;mk522;PRINIL;PRINIVIL;n-{n-[(s)-1-carboxy-3-phenylpropyl]-l-lysyl}-l-proline
CAS:76547-98-3
MF:C21H31N3O5
MW:405.49
EINECS:278-488-1
Product Categories:
Mol File:76547-98-3.mol
Lisinopril Structure
Lisinopril Chemical Properties
Melting point 162-165 °C
Boiling point 666.4±55.0 °C(Predicted)
density 1.251±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: ≥10 mg/mL
form solid
pka2.18±0.10(Predicted)
color white
CAS DataBase Reference76547-98-3(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS TW3589990
Hazardous Substances Data76547-98-3(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
Lisinopril Usage And Synthesis
OriginatorAcebitor 5,Biddle Sawyer,India
UsesLabeled Lisinopril, intended for use as an internal standard for the quantification fo Lisinopril by GC- or LC-mass spectrometry.
Manufacturing Process2-Oxo-4-phenylbutyric acid and t-BOC-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. Essentially all of the t-BOC protecting group is cleaved when the product is absorbed on strong acid ion exchange resin. The crude N-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline is eluted from the resin with 10% ammonia, freeze dried, and purified by gel filtration chromatography (LH-20). A minute peak for t-BOC protons in the NMR spectrum disappears when the product is treated with ethyl acetate that is 4 N in hydrogen chloride gas. The NMR spectrum of the resulting HCl salt of the product is consistent with structure. The mass spectrum shows a molecular ion at 693 m/e for the tetrasilylated species. Chromatography on XAD-2 resin using 3.5% acetonitrile in 0.1 molar ammonium hydroxide affords N-α-((1S)- 1-carboxy-3-phenylpropyl)-L-lysyl-L-proline. The last peptide can be produced if 2-oxo-4-phenylbutyric acid and N-t-Boc-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. The product is absorbed on strong acid ion exchange resin, and eluted with 2% pyridine in water. Product-rich cuts are stripped to a glass and treated with 4 N HCl in ethylacetate to remove the t-Boc protecting group. The resulting hydrochloride salt is converted to the free base by absorbing on strong acid ion exchange resin and eluting with 2% pyridine in water. Freeze drying of product-rich cuts affords N-α-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline as a white fluffy solid. The NMR spectrum is consistent with structure. The mass spectrum shows a molecular ion at 549 for the disilylated species. Chromatography affords the desired isomer.
Brand namePrinivil (Merck); Zestril (AstraZeneca).
Therapeutic FunctionAntihypertensive
Lisinopril Preparation Products And Raw materials
Raw materialsTrifluoroacetic acid-->L-Proline-->L-Lysine-->Sodium cyanoborohydride-->LIPOPHILIC SEPHADEX-->2-Oxo-4-phenylbutyric acid
Tag:Lisinopril(76547-98-3) Related Product Information
N6-TrifluoroAcetyl-L-Lysine,Lisinopril LISINOPRIL DIHYDRATE IMP. B (EP) AS HYDRATE: 4-METHYLBENZENESULPHONIC ACID HYDRATE Lisinopril EP,USP Lisinopril S,S,S-Diketopiperazine LISINOPRIL DIHYDRATE FOR PERFORMANCE TEST EPL(CRM STANDARD) (S)Lisinopril-D5 N6-TRIFLUOROACETYL-L-LYSINE /INTERMEDIATE OF LISINOPRIL (R) Lisinopril N6-Trrifluoroacetyl-L-lysine(for Lisinopril),N-6-TRIFLUORO ACETYL-L-LYSINE ( LISINOPRIL INTERMEDIATE ) LISINOPRIL USP 24 LISINOPRIL DIHYDRATE IMP. B (EP) AS HYDRATE: 4-METHYLBENZENESULPHONIC ACID HYDRATE MM LISINOPRIL DIHYDRATE FOR PERFORMANCE TEST LISINOPRIL DIHYDRATE IMP. A (EP): (2RS)-2-AMINO-4-PHENYLBUTANOIC ACID LISINOPRIL DIHYDRATE FOR PERFORMANCE TEST EPL LISINOPRIL ESTER,LISINOPRIL (ETHYL) ESTER Lisinopril Poly(L-lysine hydrobromide) L-Lysine hydrochloride