咖啡豆醇
| 中文名称 | 咖啡豆醇 |
|---|---|
| 中文同义词 | 咖啡豆醇 |
| 英文名称 | KAHWEOL |
| 英文同义词 | KAHWEOL;(3bS)-3b,4,5,6,7,8,9,10,10aα,10b-Decahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol;[3bS-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta)]-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol;5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol,3b,4,5,6,7,8,9,10,10a,10b-decahydro-7-hydroxy-10b-methyl-,(3bS,5aS,7R,8R,10aR,10bS)-;KAHWEOL USP/EP/BP;Kahweol DISCONTINUED, unstable |
| CAS号 | 6894-43-5 |
| 分子式 | C20H26O3 |
| 分子量 | 314.42 |
| EINECS号 | |
| 植物来源 | 咖啡豆 |
| 相关类别 | 中药对照品;对照品;色谱纯;Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 6894-43-5.mol |
| 结构式 |  |
咖啡豆醇 性质
| 熔点 | 88-90℃ |
|---|---|
| 沸点 | 476.6±45.0 °C(Predicted) |
| 密度 | 1.25±0.1 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | DMF:5.0(最大浓度 mg/mL);0.64(最大浓度 mM) DMSO:18.17(最大浓度 mg/mL);57.77(最大浓度 mM) 乙醇:5.0(最大浓度 mg/mL);0.64(最大浓度 mM) 乙醇:PBS (pH 7.2) (1:5):0.02(最大浓度 mg/mL);0.06(最大浓度 mM) |
| 酸度系数(pKa) | 14.43±0.40(Predicted) |
| 形态 | 白色至类白色固体。 |
| LogP | 3.380 (est) |
AMPK; adipogenesis; apoptosis
Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells. Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells. Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only. kahweol (0-25 μg/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells. kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism.
Western Blot Analysis
| Cell Line: | 3T3-L1 cells |
| Concentration: | 0, 5, 10, 25 μg/ml |
| Incubation Time: | |
| Result: | Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-N6258 | Kahweol | 1 mg | 480元 | |
| 2024/04/30 | HY-N6258 | 咖啡豆醇 Kahweol | 6894-43-5 | 5mg | 1200元 |