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L-Proline Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:L-Proline
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Products Intro: Product Name:2-Pyrrolidinecarboxylic acid
Purity:CP2000 Package:1Kg;25kg/ Drum or as customer request Remarks:crystalline
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:147-85-3
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Products Intro: Product Name:2-Pyrrolidinecarboxylic acid
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366
Products Intro: Product Name:L-Proline
Purity:99% Package:100g;500g;1kg;25kg...

Lastest Price from L-Proline manufacturers

  • L-Proline
  • US $100.00 / KG
  • 2019-05-13
  • CAS:147-85-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: Customized
L-Proline Basic information
Product Name:L-Proline
Synonyms:L-Poline;ccc(u);femanumber3319;L(-)-Prolin;l-alpha-pyrrolidinecarboxylicacid;l-prolin;pro(iupacabbreviation);L-PROLINE extrapure CHR
Product Categories:Amino Acids;amino;Food & Feed ADDITIVES;Amino Acid Derivatives;Proline [Pro, P];Amino Acids;Amino Acids and Derivatives;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids
Mol File:147-85-3.mol
L-Proline Structure
L-Proline Chemical Properties
Melting point 228 °C (dec.)(lit.)
alpha -85.5 º (c=4, H2O)
Boiling point 215.41°C (rough estimate)
density 1.35
refractive index -85 ° (C=4, H2O)
storage temp. Store at RT.
solubility H2O: 50 mg/mL
form powder
pka1.95, 10.64(at 25℃)
color White
PH6.0-7.0 (25℃, 1M in H2O)
optical activity[α]20/D 85.0±1.0°, c = 5% in H2O
Water Solubility soluble
Sensitive Hygroscopic
λmaxλ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
JECFA Number1425
Merck 14,7780
BRN 80810
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference147-85-3(CAS DataBase Reference)
NIST Chemistry ReferenceProline(147-85-3)
EPA Substance Registry SystemL-Proline(147-85-3)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 24/25-36/37/39-26
WGK Germany 3
RTECS TW3584000
HS Code 29339990
Hazardous Substances Data147-85-3(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: > 5110 mg/kg
MSDS Information
2-Pyrrolidinecarboxylic acid English
ACROS English
SigmaAldrich English
ALFA English
L-Proline Usage And Synthesis
Chemical PropertiesWhite crystalline powder
Chemical PropertiesL-Proline, an amino acid, is odorless or has a slight, characteristic odor with a slightly sweet taste.
OccurrenceReported found as a component in many proteins; also widely occurring as the free acid in natural products. A major constituent of collagen, the main fibrous protein found in bone, cartilage and other connective tissue.
Usesamino acid, nutrient
UsesL-Proline is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.
PreparationFrom α-piperidone; from cyclopentantone; from l-glutamic acid.
Enzyme inhibitorThis pyrrolidine (FW = 115.13 g/mol; pK1 = 1.95; pK2 = 10.64), symbolized as eithet Pro or P, is one of the twenty proteogenic amino acids. Its fivemembered ring is usually puckered, with the g carbon (position C4 of the ring) out of the plane by about 0.5 ?.There are six codons that code for Lproline: CCC, CCU, CCA, and CCG. This amino acid is unique among the twenty proteogenic amino acids in that the “side chain” is covalently linked to the nitrogen. Proline is regarded as a nonpolar amino acid; interestingly, however, most prolyl residue in proteins are located on the surface of proteins, since the steric constraints of the pyrrolidine ring results in reverse turns. Such constraints make prolyl residues incompatible with a-helical structures and b-pleated sheets. Even so, prolyl residues can be found at Ntermini of a-helices. In addition, prolyl residues can be found in long helices; the residue cause a small distortion of the helical structure. Prolyl residues are also abundant and structural important in the collagen triple helix. In homologous proteins, if a prolyl residue is interchanged, it is usually with either an alanyl or a seryl residue. The L-stereoisomer has a specific rotation of –60.4° at 25°C of the D line for a 1.0–2.0 g/100 mL solution in 5 M HCl (–86.2° in distilled water). It is soluble in water (162.3 g/100 mL at 25°C; 206.7 g/100 mL at 50°C; and 239 g/100 mL at 65 °C) and is one of the few common amino acids that is soluble in ethanol (67 g/100 mL at 19°C). It is insoluble in diethyl ether, butanol, and isopropanol. While the proline “side chain” is relatively inert, prolyl residues in certain proteins, including collagen, undergo enzyme-catalyzed hydroxylation reactions at the C3 or C4 positions. Free proline also react swith periodate to produce 2-pyrrolidone. A number of enzymes use D- or L-proline as an alternative substrate (and competitive inhibitor). These include the aminoacid dehydrogenase, the amino acid oxidases, alanine:oxo-acid aminotransferase, ornithine:oxo-acid aminotransferase, asparagine:oxo-acid aminotransferase, and amino-acid racemase. Target(s): acetylcholinesterase, weakly inhibited; 2-aminohexano-6-lactam racemase, weakly inhibited; arginase, weakly inhibited; arginine deiminase; aspartate aminotransferase; [citrate lyase] deacetylase, weakly inhibited; CTP synthetase, weakly inhibited; cysteinyl-tRNA synthetase activity of Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase; glutamine synthetase, weakly inhibited; γ-glutamyl kinase, or glutamate 5-kinase; glycine/sarcosine Nmethyltransferase; hydroxy-L-proline oxidase; membrane alanyl aminopeptidase, or aminopeptidase N; phosphorylase kinase; polar-amino-acid-transporting ATPase, histidine permease, also alternative substrate; pyrroline-5-carboxylate dehydrogenase; 1-pyrroline- 5-carboxylate reductase; pyruvate kinase; a,a-trehalose-phosphate synthase, or UDP-forming; and Xaa-Pro dipeptidase, or prolidase, or imidodipeptidase.
Purification MethodsA likely impurity is hydroxyproline. Purify L-proline via its picrate which is crystallised twice from water, then decomposed with 40% H2SO4. The picric acid is extracted with diethyl ether, the H2SO4 in solution is precipitated with Ba(OH)2, and the filtrate is evaporated. The residue is crystallised from hot absolute EtOH [Mellan & Hoover J Am Chem Soc 73 3879 1951] or EtOH/Et2O. Its solubility in H2O is >100%. It sublimes at 182-187o/0.3mm with 99.4% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. It is hygroscopic and is stored in a desiccator. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2178-2199 1961, Beilstein 22 III/IV 8, 22/1 V 31.]
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