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| | (R)-(-)-3-Pyrrolidinol hydrochloride Basic information |
| | (R)-(-)-3-Pyrrolidinol hydrochloride Chemical Properties |
| Melting point | 104-107 °C(lit.) | | alpha | -7.6°(20/D, c=3,5, CH3OH) | | refractive index | -7.8 ° (C=3.5, MeOH) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in DMSO. | | form | Solid | | color | Pale Brown | | optical activity | [α]20/D 7.6°, c = 3.5 in methanol | | BRN | 4450078 | | InChIKey | QPMSJEFZULFYTB-PGMHMLKASA-N | | CAS DataBase Reference | 104706-47-0(CAS DataBase Reference) |
| | (R)-(-)-3-Pyrrolidinol hydrochloride Usage And Synthesis |
| Chemical Properties | Llight brown crystalline | | Uses | (R)-3-Pyrrolidinol hydrochloride can be used as a building block to synthesize:
- Biaryl carboxamide functional groups containing bis-aminopyrrolidine ureas as potential antagonists of the melanin-concentrating hormone receptor-1.
- Pyrrolidinol based ionic liquids.
- Optically active 2-tritylpyrrolidine based organocatalysts.
| | Uses | (R)-(-)-3-Pyrrolidinol hydrochloride is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents. | | Uses | (R)-3-Hydroxypyrrolidine hydrochloride is used as a darifenacin Intermediate. | | Purification Methods | The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.] |
| | (R)-(-)-3-Pyrrolidinol hydrochloride Preparation Products And Raw materials |
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