- ADRENORPHIN
-
- $7.00 / 1KG
-
2020-02-19
- CAS: 88866-92-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
- ADRENORPHIN
-
- $7.00 / 1KG
-
2020-02-19
- CAS: 88866-92-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
|
| | ADRENORPHIN Basic information |
| Product Name: | ADRENORPHIN | | Synonyms: | METORPHAMIDE (FREE ACID);METORPHINAMIDE;METORPHAMIDE;H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-OH;ADRENORPHIN (FREE ACID);ADRENORPHIN;TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL;8-L-Valineadrenorphin (human) | | CAS: | 88866-92-6 | | MF: | C44H68N14O10S | | MW: | 985.16 | | EINECS: | | | Product Categories: | Neuroscience | | Mol File: | 88866-92-6.mol |  |
| | ADRENORPHIN Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | ≥27.75 mg/mL in H2O with ultrasonic; ≥5.64 mg/mL in EtOH with ultrasonic; ≥98.5 mg/mL in DMSO | | form | solid | | pka | 3.34±0.10(Predicted) |
| | ADRENORPHIN Usage And Synthesis |
| Uses | Metorphacid Trifluoroacetate Salt is amino acid sequence; protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components. | | Biological Activity | adrenorphin, also sometimes referred to as metorphamide, is an endogenous, c-terminally amidated, opioid octapeptide that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain(1). it was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well. adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist while having no effects on δ-opioid receptors(2). it possesses analgesic and respiratory deppresive properties(3).figure 1 proteolytic cleavage of proenkephalin a | | references | 1. Matsuo H, Miyata A, Mizuno K (1983). "Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour". Nature 305 (5936): 721–3.2. Weber E, Esch FS, Böhlen P et al. (December 1983). "Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain". Proceedings of the National Academy of Sciences of the United States of America 80 (23): 7362–6.3. Xu SF, Lu WX, Zhou KR et al. (April 1985). "The analgesic and respiratory depressant actions of metorphamide in mice and rabbits". Neuropeptides 6 (2): 121–31. |
| | ADRENORPHIN Preparation Products And Raw materials |
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