- Dextromethorphan HBR
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- $585.00 / 1KG
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2023-11-27
- CAS:6700-34-1
- Min. Order: 1KG
- Purity: 99% min
- Supply Ability: 20 TONS
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| | Dextromethorphan hydrobromide monohydrate Basic information |
| Product Name: | Dextromethorphan hydrobromide monohydrate | | Synonyms: | DMHM;(9α,13α,14α)-3-Methoxy-17-MethylMorphinan HydrobroMide Hydrate;3-Methoxy-17-Methyl-9α,13α,14α-Morphinan HydrobroMide Hydrate;d-3-Methoxy-N-MethylMorphinan HydrobroMide Monohydrate;DextroMethorphan hydrobroMide:Monohydrat;Morphinan,3-Methoxy-17-Methyl-, hydrobroMide, hydrate (1:1:1), (9a,13a,14a)-;D-3-METHOXY-N-METHYLMORPHINAN HYDROBROMIDE;DEXTROMETHORPHAN HYDROBROMIDE MONOHYDRATE | | CAS: | 6700-34-1 | | MF: | C18H28BrNO2 | | MW: | 370.33 | | EINECS: | 629-741-3 | | Product Categories: | Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs | | Mol File: | 6700-34-1.mol |  |
| | Dextromethorphan hydrobromide monohydrate Chemical Properties |
| Melting point | 116-119°C | | alpha | [α]D25 +26～+30° (c=1.85, H2O) | | Fp | 11 °C | | storage temp. | Store at RT | | solubility | Sparingly soluble in water, freely soluble in ethanol (96 per cent). | | form | solid | | color | White to Off-White | | PH | pH (10g/l, 25℃) : 5.2～6.5 | | BRN | 6453793 | | InChIKey | QYPSYPPSHXDFLV-UHFFFAOYSA-N | | LogP | 1.351 (est) | | CAS DataBase Reference | 6700-34-1(CAS DataBase Reference) |
| | Dextromethorphan hydrobromide monohydrate Usage And Synthesis |
| Description | Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant. However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM). DXM has been used in multimodal analgesic therapies for acute and neuropathic pain. | | Chemical Properties | White Solid | | Uses | An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates). | | Uses | Antitussive;Opioid ligand | | Definition | ChEBI: Dextromethorphan hydrobromide is the hydrobromide and monohydrate of the antitussive drug dextromethorphan. It is a hydrate and a hydrobromide. It contains a dextromethorphan. | | Brand name | Benylin DM
(Parke-Davis); Dextromethorphan Hydrobromide OROS
Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar
(Hoffmann-LaRoche-International); St. Joseph Cough Syrup
(Schering-Plough HealthCare). | | Biological Activity | Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent. |
| | Dextromethorphan hydrobromide monohydrate Preparation Products And Raw materials |
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