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| | dynorphin (1-11), Pro(10)- Basic information |
| Product Name: | dynorphin (1-11), Pro(10)- | | Synonyms: | dynorphin (1-11), Pro(10)-;dynorphin(1-11);α-Neoendorphin (swine), 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine-9-D-proline- (9CI) | | CAS: | 94596-26-6 | | MF: | C63H103N21O13 | | MW: | 1362.65 | | EINECS: | | | Product Categories: | | | Mol File: | 94596-26-6.mol |  |
| | dynorphin (1-11), Pro(10)- Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | pka | 3.60±0.21(Predicted) | | Sequence | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-{d-Pro}-Lys |
| | dynorphin (1-11), Pro(10)- Usage And Synthesis |
| Uses | [DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property[1][2]. | | in vivo | [DPro10] Dynorphin A (1-11), porcine (ICV) has analgesic effects involving thermal cutaneous (tail-flick) and chemical visceral (AcOH-induced writhing) stimuli, in which mu and kappa receptors are known to be activated differentially[2]. | | References | [1] Soderstrom K, et, al. N-alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are high affinity partial agonists at the cloned rat kappa-opioid receptor. Eur J Pharmacol. 1997 Nov 5;338(2):191-7. DOI:10.1016/s0014-2999(97)81948-6
[2] Gairin JE, et, al. [D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice. J Pharmacol Exp Ther. 1988 Jun;245(3):995-1001. PMID:2898527 |
| | dynorphin (1-11), Pro(10)- Preparation Products And Raw materials |
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