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DEBRISOQUIN SULFATE

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Company Name: Alfa Chemistry
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Products Intro: Product Name:Debrisoquine sulfate
CAS:581-88-4
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Debrisoquin sulfate；Debrisoquin;Debrisoquina;Isocaramidine;Tendor;Debrisochinum;Debrisoquine
CAS:581-88-4
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: J & K SCIENTIFIC LTD.  
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Products Intro: Product Name:Debrisoquin HeMisulfate
CAS:581-88-4
Package:100Mg,1g
Company Name: Chemsky（shanghai）International Co.,Ltd.  
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Products Intro: Product Name:Debrisoquin HeMisulfate
CAS:581-88-4
Purity:98%
Company Name: Sigma-Aldrich  
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Products Intro: Product Name:Debrisoquine
CAS:581-88-4
Purity:>=98% (TLC) Package:100mg Remarks:D1306
DEBRISOQUIN SULFATE Basic information
Product Name:DEBRISOQUIN SULFATE
Synonyms:3,4-dihydro-2(1h)-isoquinolinecarboximidamidsulfate(2:1);3,4-dihydro-2(1h)-isoquinolinecarboxamidinsulfate(2:1);3,4-Dihydro-2(1H)-isoquinolinecarboximidamide, Debrisoquin sulfate, Ro5-33071;Tendor;3,4-Dihydro-2(1H)-isoquinolinecarboxamide hemisulfate;3,4-DIHYDRO-2(1H)-ISOQUINOLINECARBOXAMIDINE 0.5 H2SO4;3,4-DIHYDRO-2-[1H]-ISOQUINOLINECARBOXAMIDINE SULFATE SALT;DEBRISOQUINE SULFATE
CAS:581-88-4
MF:C20H28N6O4S
MW:448.54
EINECS:209-472-4
Product Categories:Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides and Nucleosides;Nucleotides;Pharmaceuticals
Mol File:581-88-4.mol
DEBRISOQUIN SULFATE Structure
DEBRISOQUIN SULFATE Chemical Properties
Melting point 278-280°, 284-285° or 266-268° (H2O)
storage temp. room temp
solubility H2O: 20 mg/mL with heat
form Solid
color Pale Yellow
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 26-36
WGK Germany 3
RTECS NW7010000
ToxicityLD50 in neonate, adult rats (mg/kg): 88 ±18, 1580 ±163 orally (Goldenthal)
MSDS Information
ProviderLanguage
SigmaAldrich English
DEBRISOQUIN SULFATE Usage And Synthesis
Chemical PropertiesCrystalline Solid
OriginatorDeclinax,Roche,UK,1967
UsesAntihypertensive.
Manufacturing Process27 g of 1,2,3,4-tetrahydroisoquinoline was added at room temperature to a solution of 28 g of 2-methyl-2-isothiourea sulfate in 80 ml of water. The resulting mixture was kept at room temperature with occasional shaking. After a short period of time, methylmercaptan began to escape, and the mixture warmed up slightly. After then standing for 24 hours, crystals formed. They were filtered off and rinsed with ice cold water. Recrystallization from approximately 100 ml of water yielded 1,2,3,4-tetrahydroisoquinoline-2- carboxamidine sulfate melting at 278°C to 280°C (uncorr.).
Another batch prepared in the same manner melted at 284°C to 285°C due to a minute difference in moisture content.
Both batches prepared above analyzed correctly for (C10H13N3)2·H2SO4.
Brand nameDeclinax (HoffmannLaRoche).
Therapeutic FunctionAntihypertensive
Biochem/physiol ActionsDebrisoquine is an anti-hypertensive agent. It is metabolized by cytochrome P4502D6.
DEBRISOQUIN SULFATE Preparation Products And Raw materials
Raw materials7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
Tag:DEBRISOQUIN SULFATE(581-88-4) Related Product Information
FERROUS SULFATE DEBRISOQUIN SULFATE--N/H BENZYLGUANIDINE SULFATE (2:1) debrisoquine 1,1-DIMETHYLGUANIDINE SULFATE CHEMBRDG-BB 4015994 rac 4-Hydroxydebrisoquine Hemisulfate DEBRISOQUIN SULFATE 1,1-DIETHYLGUANIDINE SULFATE N'-BENZYLGUANIDINEACETATE 1-METHYLGUANIDINE SULFATE N-ETHYLGUANIDINIUM SULFATE