4-[4-Fluoro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]-N-[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]-2-pyrimidinamine

Request For Quotation
4-[4-Fluoro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]-N-[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]-2-pyrimidinamine Basic information
Product Name:4-[4-Fluoro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]-N-[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]-2-pyrimidinamine
Synonyms:4-[4-Fluoro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]-N-[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]-2-pyrimidinamine;CDK2/4/6-IN-2
CAS:2531748-80-6
MF:C25H30FN9
MW:475.57
EINECS:
Product Categories:
Mol File:2531748-80-6.mol
4-[4-Fluoro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]-N-[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]-2-pyrimidinamine Structure
4-[4-Fluoro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]-N-[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]-2-pyrimidinamine Chemical Properties
Boiling point 703.3±70.0 °C(Predicted)
density 1.35±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka8.11±0.10(Predicted)
Safety Information
MSDS Information
4-[4-Fluoro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]-N-[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]-2-pyrimidinamine Usage And Synthesis
UsesCDK2/4/6-IN-2 is a CKD2/4/6 inhibitor, with IC50 values less than 1 μM, 10 nM, 100 nM respectively[1].
IC 50CDK2; CDK4; CDK6
References[1] Hu Zhilong, et al. Preparation of pyrimidine derivatives and related heterocycles as CDK inhibitors for the treatment of cancer. Patent. WO2020224568 A1
4-[4-Fluoro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]-N-[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]-2-pyrimidinamine Preparation Products And Raw materials
Tag:4-[4-Fluoro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]-N-[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]-2-pyrimidinamine(2531748-80-6) Related Product Information
N-(5-(difluoromethoxy)-1H-pyrazol-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazolo[3,4-b]pyrazin-6-amine CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9) THZ1 OTS964 hydrochloride DRB