| Company Name: |
Sigma-Aldrich |
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021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
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| | ANTI-P38 MAPK Basic information |
| | ANTI-P38 MAPK Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution | | biological source | rabbit |
| WGK Germany | 3 | | Storage Class | 10 - Combustible liquids |
| | ANTI-P38 MAPK Usage And Synthesis |
| Uses | Anti-p38 MAP Kinase antibody has been used in western blotting (diluted 1:1000) using using NIH 3T3 mouse fibroblasts cell lysate and rat brain extract. It has also been used in microarray. | | General Description | P38 MAPK is a mitogen-activated protein kinase (MAPK) that belongs to serine/threonine protein kinases family and is activated in response to stress signals like- osmolarity changes, UV-irradiation, heat shock,cytokines and lipopolysaccharides (LPS). It mainly expresses in brain, muscle, thymus, spleen, heart, lung, kidney and fibroblasts. | | Biochem/physiol Actions | Mitogen-activated protein kinases (MAP kinases, MAPKs) are a family of protein kinases which are considered to play a crucial role in signal transduction pathways in mammalian cells by leading mitogenic signals to their intracellular targets. MAP kinases regulate several cellular processes, such as proliferation, differentiation, response to stress and oncogenesis. p38 MAPK is activated in response to stress signals like- osmolarity changes, ultravoilet-irradiation, heat shock, cytokines and lipopolysaccharides (LPS). It is required for phosphorylation of MAPK-activated protein kinase 2 (MAPKAPK-2). Anti-p38 MAP Kinase antibody can be used to study the differential tissue expression, specific activation requirements and intracellular localization of MAP kinase isoforms in normal and neoplastic tissues. |
| | ANTI-P38 MAPK Preparation Products And Raw materials |
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