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| | N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Basic information |
| Product Name: | N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride | | Synonyms: | N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride;4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanaminehydrochloride;NE 100 hydrochloride;N,N-Di-n-propyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine hydrochloride;NE-100;4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanaMine;NE100;NE 100;NE100 HCl | | CAS: | 149409-57-4 | | MF: | C23H33NO2.HCl | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 149409-57-4.mol |  |
| | N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Chemical Properties |
| Melting point | 94-96°C | | storage temp. | 2-8°C | | solubility | H2O: soluble15mg/mL, clear | | form | powder | | color | white to beige | | Water Solubility | H2O: 15mg/mL, clear | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. | | InChI | 1S/C21H29NO2.ClH/c1-4-22(5-2)15-13-19-11-12-20(23-3)21(17-19)24-16-14-18-9-7-6-8-10-18;/h6-12,17H,4-5,13-16H2,1-3H3;1H | | InChIKey | LPMIMPZUXJWRJJ-UHFFFAOYSA-N |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Usage And Synthesis |
| Description | NE-100 (149409-57-4) is potent inhibitor of the sigma receptor (σ) with selectivity for sigma-1 (IC50= 1.5 nM) over sigma-2 (IC50= 85 nM).1,2NE-100 suppressed ischemia-induced neuronal cell death in miceviaupregulation of GRP78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma-1-independent manner.3 | | Uses | NE-100 is a potent and selective σ1 receptor antagonist. | | Biological Activity | Potent and selective σ 1 receptor antagonist (K i = 0.86 nM) that displays > 55-fold selectivity over σ 2 receptors and > 6000-fold selectivity over D 1 , D 2 , 5-HT 1A , 5-HT 2 and PCP receptors. Exhibits reversible binding (K d = 1.2 nM) and displays antipsychotic activity in vivo . Orally active. | | Biochem/physiol Actions | NE-100 is a potent and selective σ1 receptor antagonist with an IC50 value of 1.54 +/- 0.26 nM for σ1 receptors, > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. | | storage | Store at -20°C | | References | [1] SHIGERU OKUYAMA . NE-100, a novel sigma receptor ligand: In vivo tests[J]. Life sciences, 1993, 53 18: Pages PL285-PL290. DOI:10.1016/0024-3205(93)90588-t
[2] NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain
[3] YOKO ONO. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells[J]. Biochemical and biophysical research communications, 2013, 434 4: Pages 904-909. DOI:10.1016/j.bbrc.2013.04.055 |
| | N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Preparation Products And Raw materials |
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