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| Product Name: | 3-Nitroisoxazoline | | Synonyms: | 3-Nitro-4,5-dihydroisoxazole;Isoxazole, 4,5-dihydro-3-nitro-;3-Nitroisoxazoline | | CAS: | 1121-14-8 | | MF: | C3H4N2O3 | | MW: | 116.08 | | EINECS: | | | Product Categories: | | | Mol File: | 1121-14-8.mol |  |
| | 3-Nitroisoxazoline Chemical Properties |
| Boiling point | 105-109 °C(Press: 5.5 Torr) | | density | 1.69±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C |
| | 3-Nitroisoxazoline Usage And Synthesis |
| Application | 3-Nitro-4,5-Dihydroisoxazole, as a nitrated derivative of isoxazoline, plays an important role in the preparation of various antibacterial drug molecules. | | Synthesis | A 50 ml triple-necked flask was charged with 20 mL of
95% concentrated sulfuric acid with magnetic stirring, cooled to below 0C in an ice bath and added dihydroisoxazole, stirred until all dissolved and then continued stirring for 20 min, then 95% fuming nitric acid was slowly added dropwise over 1 h. The reaction was then stirred at low temperature for 30 min. After the dropwise addition, the reaction was stirred at low temperature for 30 min, and the reaction solution was slowly poured into ice water with stirring. A white solid was precipitated. Filtering, the filter cake were washed with 5% sodium bicarbonate aqueous solution and water to neutral, the obtained 3-nitro-4,5-dihydroisoxazole was recrystallized with 80% ethanol / water solution, dried at 60 . |
| | 3-Nitroisoxazoline Preparation Products And Raw materials |
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