| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:UK4b
CAS:2171000-87-4
Package:10mg;50mg
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| Company Name: |
Shanghai meikai technology co., ltd
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| Tel: |
021-68689288 15300790979 |
| Email: |
info@mkbio.com.cn |
| Products Intro: |
Product Name:5-{[3-chloro-4-(4-cyclohexylbutoxy)phenyl]methylidene}-1,3-diazinane-2,4,6-trione;UK4b
CAS:2171000-87-4
Purity:98% Package:100mg/2000; 250mg/4500; 500mg/7500
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| Product Name: | UK4b | | Synonyms: | UK4b;2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[[3-chloro-4-(4-cyclohexylbutoxy)phenyl]methylene]-;5-{[3-chloro-4-(4-cyclohexylbutoxy)phenyl]methylidene}-1,3-diazinane-2,4,6-trione | | CAS: | 2171000-87-4 | | MF: | C21H25ClN2O4 | | MW: | 404.89 | | EINECS: | | | Product Categories: | | | Mol File: | 2171000-87-4.mol |  |
| density | 1.251±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 7.037±0.20(predicted) | | form | Solid | | color | Off-white to yellow |
| Uses | UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice[1]. | | in vivo | UK4b (10-20 mg/kg; s.c.; twice daily for 22 consecutive days) can block the further growth of abdominal aortic aneurysms (AAA) in an ApoE?/? angiotensin (Ang) II (1000 ng/kg/min; infusion for 28 consecutive days) -induced mouse model of AAA[1]. | | References | [1] Weaver L M, et al. A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model[J]. Scientific Reports, 2024, 14(1): 6959. DOI:10.1038/s41598-024-57437-9 |
| | UK4b Preparation Products And Raw materials |
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