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| | magnolamine Basic information |
| Product Name: | magnolamine | | Synonyms: | magnolamine;(1S)-1,2,3,4-Tetrahydro-1-[[4-[4-hydroxy-5-methoxy-2-[[(1S)-1,2,3,4-tetrahydro-7-hydroxy-6-methoxy-2-methylisoquinolin-1-yl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methylisoquinolin-7-ol;7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[[4-[4-hydroxy-5-methoxy-2-[[(1S)-1,2,3,4-tetrahydro-7-hydroxy-6-methoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-, (1S)- | | CAS: | 573-73-9 | | MF: | C37H42N2O7 | | MW: | 626.74 | | EINECS: | | | Product Categories: | | | Mol File: | 573-73-9.mol |  |
| | magnolamine Chemical Properties |
| Melting point | 117-9°C | | Boiling point | 768.0±60.0 °C(Predicted) | | density | 1.254±0.06 g/cm3(Predicted) | | pka | 10.12±0.25(Predicted) |
| | magnolamine Usage And Synthesis |
| Description | This bisbenzylisoquinoline alkaloid is found in the benzene-soluble portion of
the total alkaloids extracted from Magnolia fuscata. When recrystallized from
C6H6 it yields fine, colourless needles, soluble in alkalies, CHC13 and EtOH. It is
dextrorotatory with [α]D + 111.6° and yields a crystalline picrate, m.p. 142-
SoC (dec.); a picrolonate, m.p. 163-4°C and a tetramethyl ether, m.p. lSI-2°C.
The latter may be oxidized by KMn04 in Me2CO to give 1-keto-6:7-dimethoxy-
2-methyltetrahydroisoquinoline, m.p. 124-5°C and magnolaminic acid,
C16H1407, m.p. 280-loC. The alkaloid acts as a cardiac depressant at between
10 to 500 parts per million. | | References | Proskurnina, Orekhov., Bull. Soc. Chim., 5, 1357 (1938)
Proskurnina., J. Gen. Chem. USSR., 16, 129 (1946)
Tomita.,J. Pharm. Soc., Japan, 1075 (1951)
Tomita, Kugo., Chem. Abstr., SO, 1056 (1956)
Pharmacology:
Buchi., Schweiz. Apoth. Zeit., 83, 198 (1945) |
| | magnolamine Preparation Products And Raw materials |
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