| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:8-iso Prostaglandin F2α-d4
CAS:211105-40-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shanghai Universal Biotech Co.,Ltd
|
| Tel: |
18768175414 |
| Email: |
gaojun@univ-bio.com |
| Products Intro: |
Product Name:8-iso Prostaglandin F2α-d4
CAS:211105-40-7
Package:50ug Remarks: 见优宁维官网
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| Company Name: |
Shanghai Maclean Biochemical Technology Co., LTD
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| Tel: |
021-50706066 15221275939 |
| Email: |
shenlinxing@macklin.cn |
| Products Intro: |
Product Name:8-iso Prostaglandin F2α-d4
CAS:211105-40-7
Purity:>=98%， 100ug/ml in methyl acetate Package:50μg
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| | 8-EPI PGF2ALPHA-D4 Basic information |
| Product Name: | 8-EPI PGF2ALPHA-D4 | | Synonyms: | IPF2ALPHA-IIID4;8-iso Prostaglandin F2α-d4;8-ISO PROSTAGLANDIN F2ALPHA-D4;8-ISOPROSTANE-D4;8-EPI PGF2ALPHA-D4;9ALPHA, 11ALPHA, 15S-TRIHYDROXY-(8BETA)-PROSTA-5Z, 13E-DIEN-1-OIC-3,3,4,4-D4 ACID;PXGPLTODNUVGFL-FLRLWOSLSA-N;8-iso Prostaglandin F2α-d4 | | CAS: | 211105-40-7 | | MF: | C20H30D4O5 | | MW: | 358.51 | | EINECS: | | | Product Categories: | | | Mol File: | 211105-40-7.mol |  |
| | 8-EPI PGF2ALPHA-D4 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | 10 mM Na2CO3: >6.5 mg/ml (from PGF2a),DMF: >100 mg/ml (from PGF2a),DMSO: >100 mg/ml (from PGF2a),Ethanol: >100 mg/ml (from PGF2a),PBS pH 7.2: >10 mg/ml (from PGF2a) |
| | 8-EPI PGF2ALPHA-D4 Usage And Synthesis |
| Biological Activity | 8-iso PGF2α-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-iso PGF2α by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.1,2,3 It circulates in human plasma in two distinct forms - esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.1,2 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.4 Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively.3 | | References | 1.Morrow, J.D., Hill, K.E., Burk, R.F., et al.A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanismProc. Natl. Acad. Sci. U.S.A.87(23)9383-9387(1990)
2.Morrow, J.D., Harris, T.M., and Roberts, L.J., IINoncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoidsAnal. Biochem.184(1)1-10(1990)
3.Morrow, J.D., Minton, T.A., and Roberts, L.J., IIThe F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonistProstaglandins44(2)155-163(1992)
4.Kiriyama, M., Ushikubi, F., Kobayashi, T., et al.Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cellsBr. J. Pharmacol.122(2)217-224(1997) |
| | 8-EPI PGF2ALPHA-D4 Preparation Products And Raw materials |
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