| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Reversan
CAS:313397-13-6
Package:100Mg,10Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Reversan;N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyriMidine-3-carboxaMide
CAS:313397-13-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | Reversan Basic information |
| Product Name: | Reversan | | Synonyms: | N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide;Reversan;CBLC4H10;5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-;ReversanQ: What is
Reversan Q: What is the CAS Number of
Reversan Q: What is the storage condition of
Reversan Q: What are the applications of
Reversan | | CAS: | 313397-13-6 | | MF: | C26H27N5O2 | | MW: | 441.52 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 313397-13-6.mol |  |
| | Reversan Chemical Properties |
| Melting point | 176-180°C | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO: ≥8mg/mL at ~60°C | | pka | 11.33±0.46(Predicted) | | form | powder | | color | faint yellow to yellow |
| | Reversan Usage And Synthesis |
| Uses | Reversan represents a new class of nontoxic MRP1 inhibitor, which may be clinically useful for the treatment of neuroblastoma. | | Biological Activity | Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin , vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Displays at activity on MRP2, MRP3, MRP5 and MRP5 transporters. | | storage | Store at -20°C |
| | Reversan Preparation Products And Raw materials |
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