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| Product Name: | STATIL | | Synonyms: | 3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL);3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid;ICI-128436;ICI-plc;MK-538;2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid;Ponalrestat Statil;STATIL | | CAS: | 72702-95-5 | | MF: | C17H12BrFN2O3 | | MW: | 391.19 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 72702-95-5.mol |  |
| | STATIL Chemical Properties |
| Melting point | 184-186℃ (DEC.) | | density | 1.60 | | storage temp. | Store at RT | | solubility | DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL | | form | A crystalline solid |
| | STATIL Usage And Synthesis |
| Description | Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes. | | Uses | Inhibitor (aldose reductase). | | Uses | Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth | | Definition | ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines. | | Biological Activity | Potent aldose reductase inhibitor. |
| | STATIL Preparation Products And Raw materials |
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