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| | (S)-1-Boc-3-hydroxypiperidine Basic information | | Uses |
| | (S)-1-Boc-3-hydroxypiperidine Chemical Properties |
| Melting point | 34-40 °C | | Boiling point | 292.3±33.0 °C(Predicted) | | density | 1.107±0.06 g/cm3(Predicted) | | Fp | 110 °C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in methanol. | | pka | 14.74±0.20(Predicted) | | form | Powder or Crystalline Powder | | color | White to tan | | optical activity | [α]22/D +10.0°, c = 1 in chloroform | | InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1 | | InChIKey | UIJXHKXIOCDSEB-QMMMGPOBSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1 | | CAS DataBase Reference | 143900-44-1(CAS DataBase Reference) |
| | (S)-1-Boc-3-hydroxypiperidine Usage And Synthesis |
| Uses | (S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma. | | Description | (S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield. | | Chemical Properties | White powder | | Uses | A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase. | | Uses | (S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate. |
| | (S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials |
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