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2-Hydroxypropyl-β-cyclodextrin

2-Hydroxypropyl-β-cyclodextrin Suppliers list
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN
CAS:128446-35-5
Purity:99% Package:1KG;1USD
Company Name: Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
Tel: 13562317646
Email: bob.zhao@cydextrin.com
Products Intro: Product Name:hydroxypropyl-beta-cyclodextrin
CAS:128446-35-5
Purity:99.5% Package:1Kg/Bag;50USD|2Kg/Bag;50USD|10Kg/Drum;50USD|20Kg/Drum;50USD
Company Name: Qingdao kaimoshi biochemical technology co., ltd.
Tel: +(86) 571 87700752
Email: info@kaimosi.com
Products Intro: Product Name:2-Hydroxypropyl-beta-cyclodextrin
CAS:128446-35-5
Purity:99% Package:20Kg/Bag;0USD
Company Name: Hebei Ruiyao Biotechnology Co. Ltd
Tel: 15632182983 15532235888
Email: admin@ruiyaobio.com
Products Intro: Product Name:2-Hydroxypropyl-β-cyclodextrin
CAS:128446-35-5
Package:1KG
Company Name: Hebei Qige Biological Technology Co. Ltd
Tel: 8618733132031
Email: qige01@hbqige.com
Products Intro: Product Name:2-Hydroxypropyl-β-cyclodextrin
CAS:128446-35-5
Purity:99% Package:25kg/barrel

2-Hydroxypropyl-β-cyclodextrin manufacturers

2-Hydroxypropyl-β-cyclodextrin Basic information
Product Name:2-Hydroxypropyl-β-cyclodextrin
Synonyms:beta-cyclodextrin,2-hydroxypropylether;(2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1340;(2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1400;Hydroxypropyl-beta-cyclodextrin,97%;(2-Hydroxypropyl)-beta-cyclode;(2-Hydroxypropyl)-beta-cyclodextrin, avge. MW ca 1400;(2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480;(2-Hydroxypropyl)-β-cyclodextrin ,97%
CAS:128446-35-5
MF:C63H112O42
MW:1541.54
EINECS:420-920-1
Product Categories:Other APIs;Carbohydrates & Derivatives;CyclodextrinsSynthetic Reagents;Cell Signaling and Neuroscience;Lipids and Lipid Carriers;Reagents and Supplements;Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Chelation/Complexation Compounds;Signal Transduction Research Tools;Synthetic Reagents;CyclodextrinsCell Culture
Mol File:128446-35-5.mol
2-Hydroxypropyl-β-cyclodextrin Structure
2-Hydroxypropyl-β-cyclodextrin Chemical Properties
Melting point 278 °C (dec.)
refractive index 125 ° (C=1, H2O)
storage temp. room temp
solubility H2O: 45 % (w/v)
form solution (clear, colorless)
color White to slightly yellow
optical activity[α]26/D +139°, c = 1 in H2O
Water Solubility Soluble in water.
InChIKeyODLHGICHYURWBS-FOSILIAISA-N
EPA Substance Registry System.beta.-Cyclodextrin, 2-hydroxypropyl ethers (128446-35-5)
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS GU2293332
TSCA Yes
HS Code 29400090
MSDS Information
ProviderLanguage
SigmaAldrich English
2-Hydroxypropyl-β-cyclodextrin Usage And Synthesis
Chemical PropertiesWhite to slightly yellow powder
Chemical PropertiesHydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.
Uses2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.
Usesenteric coating, sustained release formulations, buccal and transdermal drug delivery
Uses2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis
Production MethodsHydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.
Pharmaceutical ApplicationsHydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.
SafetyThe pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.
storageStore in well-closed containers.
Regulatory StatusIncluded in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.
2-Hydroxypropyl-β-cyclodextrin Preparation Products And Raw materials
Tag:2-Hydroxypropyl-β-cyclodextrin(128446-35-5) Related Product Information
beta-Cyclodextrin hydrate BETA-CYCLODEXTRIN CINNARIZINE HYDROXYPROPYL-BETA-CYCLODEXTRIN COMPLEX CNQX:2-HYDROXYPROPYL-BETA-CYCLODEXTRIN HYDROXYPROPYL-BETA-CYCLODEXTRIN 1,2-O-(2,2,2-TRICHLOROETHYLIDENE)-ALPHA-D-GLUCOFURANOSE: 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN COMPLEX (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN propofol hydroxypropyl-beta-cyclodextrin 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN SUCCINATE CARBAMAZEPINE-2-HYDROXYPROPYL-BETA-CYCLODEXTRIN COMPLEX SUCCINYL-(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN .alpha.-D-Arabinopyranoside, methyl D-(+)-DIGITOXOSE 6-Deoxy-L-glucose L-SORBITOL METHYL-Β-D-ARABINO- PYRANOSIDE 2-Hydroxypropyl-β-cyclodextrin 1,5-ANHYDRO-L-GLUCITOL