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Sulfanilamide

Sulfanilamide Suppliers list
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Email: info@tnjchem.com
Products Intro: Product Name:Sulfanilamide
CAS:63-74-1
Purity:99.9% Package:1KG;5USD
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:INDUSTRIAL SULFA
CAS:63-74-1
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
Email: fandachem@gmail.com
Products Intro: Product Name:Sulfanilamide
CAS:63-74-1
Purity:99% Package:25kg/drum
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: Product Name:Sulfanilamide
CAS:63-74-1
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Sulfanilamide
CAS:63-74-1
Purity:HPLC>=98% Package:100mg

Lastest Price from Sulfanilamide manufacturers

  • Sulfanilamide
  • US $1.00 / kg
  • 2019-07-06
  • CAS:63-74-1
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1000kg
  • Sulfanilamide
  • US $1.00 / KG
  • 2019-07-06
  • CAS:63-74-1
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
  • Sulfanilamide
  • US $100.00 / KG
  • 2019-05-22
  • CAS:63-74-1
  • Min. Order: 100g
  • Purity: 99.8%
  • Supply Ability: 5tons
Sulfanilamide Chemical Properties
Melting point 164-166 °C(lit.)
Boiling point 400.5±47.0 °C(Predicted)
density 1.08
vapor pressure 0.00001 hPa (70 °C)
refractive index 1.6490 (estimate)
storage temp. 0-6°C
solubility 5.37g/l
pkapKa 10.65(H2O t = 25.0±0.5 I = 0.2) (Uncertain)
form powder
color white to faintly beige
PH5.8-6.1 (5g/l, H2O, 20℃)
Water Solubility 7.5 g/L at 25 ºC
λmax257nm(H2O)(lit.)
Merck 14,8925
BRN 511852
InChIKeyFDDDEECHVMSUSB-UHFFFAOYSA-N
CAS DataBase Reference63-74-1(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenesulfonamide, 4-amino-(63-74-1)
EPA Substance Registry SystemSulfanilamide (63-74-1)
Safety Information
Hazard Codes Xn
Risk Statements 40
Safety Statements 24/25-36-22
WGK Germany 3
RTECS WO8400000
10
TSCA Yes
HazardClass 8
HS Code 29350090
Hazardous Substances Data63-74-1(Hazardous Substances Data)
ToxicityLD50 orally in mice: 3.8 g/kg (Marshall)
MSDS Information
ProviderLanguage
Sulfanilamide English
SigmaAldrich English
ACROS English
ALFA English
Sulfanilamide Usage And Synthesis
Product featuresSulfanilamide is an organic sulfur compound structurally similar to p-aminobenzoic acid (PABA) with antibacterial property. Sulfanilamide competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.Without it, bacteria cannot replicate.
  1. Mechanism of action: mechanism of action is to interfere with the synthesis of nucleic acids required for pathogenic microorganisms,making bacteria lack of nutrition and stop the growth, development and reproduction, having suppression killing effect on hemolytic streptococcus, staphylococcus and meningococcal.
  2. Pharmacodynamics: Oral easily absorbed from the gastrointestinal tract, widely distributed in the body, can penetrate the blood-brain barrier into the brain tissue, and can penetrate the placental barrier into the fetus. Rapid excretion, mainly excreted in metabolites from kidney.
  3. Clinical application: Mainly used for trauma infection caused by infection hemolytic streptococcus, staphylococcus, and local wound infections.
  4. Uses: Sulfanilamide is lower toxicity in sulfa drugs, can be applied for infants, pregnant women, pregnant women and during menstruation, but not in large doses. Having effects on hemolytic streptococcal infection (erysipelas, puerperal fever, tonsillitis), urinary tract infection (gonorrhea) and so; also the intermediate for synthesis of other sulfa drug (such as sulfa amidine, pyrimidine and sulfamethoxazole sulfa methoxy-triazine, etc. ).
Chemical propertiesWhite granular or crystalline powder, odorless. Slightly bitter taste. Slightly soluble in water, ethanol, methanol, ether and acetone, soluble in boiling water, glycerol, hydrochloric acid, sodium hydroxide and potassium hydroxide solution, insoluble in chloroform, ether, benzene, petroleum ether.
Uses
  1. Sulfanilamide is the main raw material for the synthesis of sulfa drugs.
  2. Used as a reagent to determine nitrite, also used in the pharmaceutical industry.
  3. Used as intermediates for the synthesis of other sulfa drugs, even for wound disinfection.
  4. Amino benzene sulfonamide is intermediate of herbicide asulam, as well as intermediate of sulfa medicine.
  5. Veterinary medicine, topical anti-inflammatory drugs, for analysis and detection.
  6. Wide spectrum antibacterial, having antibacterial effects on hemolytic streptococcus, Neisseria meningitidis, Staphylococcus aureus and other Gram-positive and negative bacteria. This product is topical application, it can be partially absorbed from the wound. For trauma infections of hemolytic streptococcus and staphylococcus. It can also be used to quickly stop the bleeding wound.
Production methodsThere are several methods for their preparation.
1. Acetyl aniline used as raw material
The acetanilide reacts with chlorosulfonic acid at 40~50 ℃, and then cooled slowly, added to water for acid decomposition, while precipitation, dried and filtered to give acetaminophen chloride and ammoniated, ammoniated temperature is controlled at 40~45 ℃, hydrolysis, acidification.
2. Method of mixed diphenyl urea
Condensation of aniline and urea is single-phenylurea and diphenyl urea (called mixed urea), and then obtained from chlorosulfonated, amination, hydrolysis, acid precipitation. The reaction procedure is as follows.
(1)Condensation condensation of aniline hydrochloride and urea, at a temperature of 101~110 ℃ reaction for 3~4 h, obtaining mixed diphenyl urea.
(2)Chlorosulfonated Chlorine acid is pressed into the sulfonated pot, stirring cooling, when the temperature drops below 10 ℃, uniformly added mixed phenyl urea under stirring, the reaction temperature is gradually increased, the addition is completed, at the 46~50 ℃ insulation and mixing for 2 h, cooled to below 10 ℃, added water for acid decomposition. Controlling that the decomposition temperature does not exceed 15 ℃, after the addition of water continued stirring for 20min, then by precipitation, washed with water, obtaining mixed phenylurea chloride.
(3)Ammoniated 2% aqueous ammonia is put into ammoniated pan, cooled to 25 ℃, stirring and added into a mixing phenyl urea chloride, control the temperature at 40 ℃, insulation and reaction for 3h, obtaining ammoniated liquid.
(4)Hydrolysis and neutralization The amide is heated up to 90 ℃, is added 3% lye, continue to heat 108~112 ℃, hydrolysis for 5 h, and moved in the crystallization pot, added hydrochloric acid to neutralize crystals and the crystals are cooled to 20 ℃, crystallization, filtration, washed with water, dry, products are obtained.
UsesThe active metabolite of the antibacterial dye, Sulfamidochrysoidine. Inhibits folic acid synthesis in prokaryotes. Antibacterial.
DefinitionA type of organic compound with the general formula R.SO2.NH2. Sulfonamides, which are amides of sulfonic acids, are active against bacteria, and some are used in pharmaceuticals (‘sulfa drugs’).
Brand nameAcetonal vaginal;Amidrin;Avc cream suppositoty;Avc/dienestrol;Avril;Azol polvo;Azol pomada;Buco pental;Buco regis;Chemiovis;Daromid;Defonamid;Dorsec;Expseptoplix;Faderma;Fricton;Gagaril sulfamida;Gynaedron;Instilin;Jacosulfon;Medeyol;Mentol sedans sulfamidad;Nasopomada;Odamida;Oestro-gyneadron;Otocaina;Otonasal;Otorrilan;Ovuthricinol;Oxidermiol;Paraseptol;Pental forte;Pentalmicina;Polvo sulfamida leti;Polvo sulfamida orrvan;Polvos wilfe;Pomada heridas;Pomada wilfe;Prontablin;Pulvi bacteramide;Pyodental;Pyodron;Quimpeamida;Rhinamide;Rino glucol sulf;Sulfacromo;Sulfonamid spuman;Sulfonamide-spuman-style;Sulfonanilamid;Sulfosellan-salbe;Ung. vemleigh.
World Health Organization (WHO)Sulfanilamide, a sulfonamide anti-infective agent, was introduced in 1936 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfanilamide is still used in some countries as a pessaries or as vaginal cream.
General DescriptionWhite powder. pH of 0.5% aqueous solution: 5.8-6.1.
Air & Water ReactionsMay be unstable if exposed for long periods air and light . Slightly water soluble.
Reactivity ProfileSulfanilamide is an amino acid. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May react with azo and diazo compounds to generate toxic gases.
Fire HazardFlash point data for Sulfanilamide are not available but Sulfanilamide is probably combustible.
Safety ProfilePoison by intraperitoneal route. Moderately toxic by ingestion, subcutaneous, and intravenous routes. Human teratogenic effects by unspecified route: developmental abnormalities of the blood and lymphatic systems (including the spleen and bone marrow). Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Tag:Sulfanilamide(63-74-1) Related Product Information
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