| | DIHYDROERGOTAMINE MESYLATE Basic information |
| Product Name: | DIHYDROERGOTAMINE MESYLATE | | Synonyms: | dihydroergotoxin;dihydro-ergotoxin;DIHYDROERGOTAMINE MESYLATE;DIHYDROERGOTAMINE METHANESULFONATE;DIHYDROERGOTAMINE METHANESULFONATE SALT;Dihydroergotoxine;8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotoxine deriv.;9,10-Dihydroergotoxine | | CAS: | 11032-41-0 | | MF: | C34H41N5O8S | | MW: | 679.78 | | EINECS: | | | Product Categories: | | | Mol File: | 11032-41-0.mol |  |
| | DIHYDROERGOTAMINE MESYLATE Chemical Properties |
| solubility | methanol: 21 mg/mL | | form | powder | | color | white |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | KE7920000 | | Toxicity | mouse,LD50,subcutaneous,71mg/kg (71mg/kg),Russian Pharmacology and Toxicology Vol. 31, Pg. 53, 1968. |
| | DIHYDROERGOTAMINE MESYLATE Usage And Synthesis |
| Originator | Redergin,Lek | | Uses | Cognition adjuvant. | | Manufacturing Process | Dihydrotoxine is a mixture of three hydrogenated alkaloides of ergot spur.
(Claviceps purpurea). 10 g ergotoxine (the mixture of ergocornine,
ergocristine, ergocryptine 1:1:1) in 200 ml dioxane and 20 g Pd/BaSO4 were
stirred at a H2 pressure 10 atmospheres at 80°C for 5 hours. The catalyst was
filtered off, a filtrate was distilled to dryness in vacuum. The residue was in
chloroform dissolved and shook with aluminum oxide. The Al2O3 was filtered
off, the filtrate was crystallized after adding of hot benzene and cooling. Yield
6-8 g dihydroergotoxine. It crystallized with 1 mol of benzene. MP: 185°C. | | Brand name | Alkergot (Sandoz); Circanol(3M Pharmaceuticals); Deapril (Bristol-Myers Squibb);Gerimal (Watson); Hydergine (Novartis). | | Therapeutic Function | Vasodilator |
| | DIHYDROERGOTAMINE MESYLATE Preparation Products And Raw materials |
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