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Dihydroergotoxine mesylate

Dihydroergotoxine mesylate Suppliers list
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Products Intro: Product Name:Dihydroergotoxine mesylate 8067-24-1
CAS:8067-24-1
Purity:99% Package:25KG;5KG;1KG
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Products Intro: Product Name:Dihydroergotoxine mesylate
CAS:8067-24-1
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Products Intro: Product Name:ergoloid mesylate
CAS:8067-24-1
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Products Intro: Product Name:Dihydroergotoxine mesylate
CAS:8067-24-1
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Products Intro: CAS:8067-24-1
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Dihydroergotoxine mesylate manufacturers

Dihydroergotoxine mesylate Basic information
Product Name:Dihydroergotoxine mesylate
Synonyms:cck179;co-dergocrinemesylate;dihydroergotoxinemesilate;dihydroergotoxinemethanesulfonate;dihydroergotoxinemethanesulphonate;dihydroergotoxinemonomethanesulfonate(salt);dihydroergotoxinmesylate;dihydroergotoxinmethanesulfonate
CAS:8067-24-1
MF:C20H29N3O5S
MW:423.53
EINECS:
Product Categories:
Mol File:8067-24-1.mol
Dihydroergotoxine mesylate Structure
Dihydroergotoxine mesylate Chemical Properties
storage temp. Store at RT
form neat
Safety Information
Hazard Codes T
Risk Statements 60
Safety Statements 53-36/37/39-45
RIDADR 1544
RTECS KE8800000
HazardClass 6.1(b)
PackingGroup III
HS Code 3003490000
MSDS Information
Dihydroergotoxine mesylate Usage And Synthesis
DescriptionErgoloid is a mixture of the ergot alkaloids dihydroergocornine, dihydroergocrystine, and dihydroergocryptine. It blocks reflex vasodilation and vasoconstriction induced by norepinephrine in dogs when injected into the kidney at a dose of 0.15 mg. Ergoloid blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner. It also acts as an erectogenic agent in rats. Formulations containing ergoloid have been used in the treatment of migraine headaches and vascular dementias.
UsesCognition adjuvant.
DefinitionChEBI: A mixture of hydrogenated ergot alkaloids consisting of the methanesulfonic acid salts of dihydroergocornine (R = CHMe2), dihydroergocristine (R = CH2Ph), and alpha- and beta-dihydroer ocryptine (R = CH2CHMe2 and CH(Me)Et, respectively). It is used for the symptomatic treatment of mild to moderate dementia in the elderly, although its value is not established.
Brand nameAlkergot (Sandoz); Circanol(3M Pharmaceuticals); Deapril (Bristol-Myers Squibb);Gerimal (Watson); Hydergine (Novartis).
PharmacologyThe metabolic effects of ergoloid mesylates (Hydergine) may include enhancement of noradrenergic, dopaminergic and serotoninergic neurotransmission (Weil,1988) and reduction of free radicals. Schneider and Olin (1994) reviewed 151 reports on the use of Hydergine in senile dementia, but only 47 of these trials (31%) met strict criteria for meta-analysis. ACochrane review (Olin et al., 2001) confirmed that patients with VaD appeared to benefit more than patients with AD in terms of cognition,clinical global ratings and combined measures. However, compared with placebo, efficacy was very modest. Thus, there are no grounds to recommend its use.
Dihydroergotoxine mesylate Preparation Products And Raw materials
Tag:Dihydroergotoxine mesylate(8067-24-1) Related Product Information
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