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AJMALINE

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Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:4360-12-7
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
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Products Intro: CAS:4360-12-7
Purity:98% Package:g-Kg Remarks:White to pale yellow crystalline powder
Company Name: Chengdu Biopurify Phytochemicals Ltd.
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Products Intro: Product Name:Ajmaline
CAS:4360-12-7
Purity:90%~98% HPLC Package:20mg;100mg;500mg;1g Remarks:BP4189
Company Name: BOC Sciences
Tel: 1-631-485-4226
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Products Intro: Product Name:Ajmaline
CAS:4360-12-7
Purity:>95% Package:$268/250mg Remarks:Ajmaline is an alkaloid which could be extracted from Rauwolfia serpentina. It is an antiarrhythmic agent, acting through changing the shreshold and the shape of cardiac action potentials.
Company Name: TopScience Biochemical
Tel: 00852-68527855
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Products Intro: Product Name:Ajmaline
Purity:99.9% Package:1g;USD|50g;USD

AJMALINE manufacturers

  • AJMALINE USP/EP/BP
  • $1.10 / g
  • 2021-08-12
  • CAS:4360-12-7
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
AJMALINE Basic information
Product Name:AJMALINE
Synonyms:AJMALAN-17,21-DIOL,(17R,21)-;AJMALINE;21-diol,(17r,21-alpha)-ajmalan-1;5H-6,10:11,12a-Dimethanoindolo[3,2-b]quinolizine, ajmalan-17,21-diol deriv.;Ajmalan-17,20-diol;Ajmalan-17,21-diol;Ajmalan-17,21-diol, (17R,21alpha)-;Ajmalin
CAS:4360-12-7
MF:C20H26N2O2
MW:326.44
EINECS:224-439-4
Product Categories:Alkaloids;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:4360-12-7.mol
AJMALINE Structure
AJMALINE Chemical Properties
Melting point 189°C
alpha D18 +131° (c = 0.4 in chloroform); D20 +144° (c = 0.8 in chloroform)
Boiling point 464.47°C (rough estimate)
density 1.1117 (rough estimate)
refractive index 1.6800 (estimate)
storage temp. 2-8°C
pkapKa 8.2 (Uncertain)
Water Solubility 489.7mg/L(30 ºC)
Merck 13,194
Safety Information
Hazard Codes Xn
Risk Statements 25-20/21/22
Safety Statements 13-45-36
RIDADR 1544
RTECS AX8050000
HazardClass 6.1(b)
PackingGroup III
ToxicityLD50 oral in rat: 360mg/kg
MSDS Information
AJMALINE Usage And Synthesis
DescriptionRauwolfia (Luo Fu Mu) is derived from the plants Rauvolfia verticillata (Lour.) Baill. and R. yunnanensis Tsiang, and the root is usually used as its medicinal part. R. verticillata (Lour.) Baill. var. hainanensis Tsiang and R. vomitoria Afzel. ex Spreng have been also used as traditional Chinese herb.
Rauwolfia is one of the important traditional herbs in southern China. Its scope of treatment includes cold, fever, sore throat, headache, and dizziness caused by hypertension, abdominal pain and diarrhea, scabies, and so on. Rauwolfia is also used to treat insomniac dizziness, bruises, sprains, and venomous snake bites in folk.
In the “Flora of China,” 135 species of Rauwolfia were recorded, mostly distributed in the tropics and subtropics, a few in the temperate regions. There are nine species, four varieties, and three cultivated species in China.
Chemical PropertiesWhite Solid
Physical propertiesAppearance: white or yellowish crystal powder. Melting point: its anhydride is 205– 207?°C. Optical rotation: +144° (chloroform). Solubility: well soluble in organic solvents, such as methanol, ethanol, etc., and slightly soluble in water. Storage temperature: 2–8?°C.
OriginatorAjmaline ,Solvay Pharma
HistorySince 1930s, abundant studies have been focused on the Rauwolfia plants. So far, a total of 91 alkaloids were separated from Rauwolfia, and the identification of the chemical structures was obtained, including 2 non-indole alkaloids (thebaine and papaverine) and 89 indole alkaloids . In accordance with the basic framework, indole alkaloids can be divided into seven classes, such as the ajmaline class, the
UsesAn antiarrhythmic agent isolated from Rauwolfia serpentina.
UsesFor use as an antiarrhythmic agent.
DefinitionChEBI: A monoterpenoid indole alkaloid that consists of ajmalan substituted at positions 17 and 21 by hydroxy groups.
Manufacturing ProcessAjmaline isolated from Rauwolfia sp. roots: Rauwolfia serpentine Benth., Rauwolfia vomitoria Afr., Rauwolfia canescens L.
Threshed roots of Rauwolfia canescens L. extracted with 5% solution of acetic acid at room temperature for 24 h. Then extract was decanted to flask. This extract was alkalified with ammonia (alkaloid salts were converted to alkaloid bases). The obtained thus method solution was extracted with chloroform 3 or more times. Then chloroform extract was chromatographed on column through Al2O3 sorbent. After chromatography ajmalin was obtained, which had melting point at 205°C (recyrstallization from methanol).
Therapeutic FunctionAntiarrhythmic
PharmacologyAnti-arrhythmic R. serpentina (She Geng Mu) is the first anti-arrhythmic herbal medicine in the psychiatry history. Ajmaline has a potent anti-arrhythmic effect for treating atrial and ventricular arrhythmias and also has a good effect on the treatment of Wolff-Parkinson-White syndrome. Ajmaline plays a main role in decreasing the permeability of sodium ion on the myocardial cell membrane by moderately inhibiting the sodium channel. The electrophysiological effect of ajmaline is similar to that of quinidine, but it is stronger than quinidine.
In addition, ajmaline has a mild anti-sympathetic effect. It affects sympathetic nerve endings to release more sodium, dilate the coronary artery, relax vascular smooth muscle, and then decrease blood pressure. Therefore, it is suitable for clinical treatment of atrial and ventricular premature beats, pre-excitation syndrome with supraventricular tachycardia, but not suitable for the treatment of paroxysmal
atrial fibrillation and sinus tachycardia.
Clinical UseAjmaline has the anti-arrhythmic effects for the treatment of atrial or ventricular extrasystoles, paroxysmal supraventricular or ventricular tachycardia, and paroxysmal atrial fibrillation. The lethal dose for human ranged from 100 to 500?mg/kg.
Purification MethodsAjmaline crystallises from MeOH or EtOAc containing a little H2O to give the trihydrate m 158-160o. This loses 1H2O at 110o and all H2O at 150o. [Beilstein 23 III/IV 3212.]
ReferencesLe Gall., Ann. ph arm. franc., 18,817 (1960)
AJMALINE Preparation Products And Raw materials
Raw materialsAmmonia-->Acetic acid
Tag:AJMALINE(4360-12-7) Related Product Information
(17R,21-alpha)-17,21-Dihydroxy-4-(2-hydroxy-3-pyrrolidinopropyl)ajmala nium 5A,6,7,8,9,10,11,11A-OCTAHYDRO-5H-CYCLOOCT[B]INDOLE 2-PHENETHYL-PIPERIDINE 4-METHYL-1-PHENYL-2-PENTANOL Prajmaline METHYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE 3-PIPERIDIN-2-YL-PROPAN-1-OL N,N-DIISOPROPYLISOBUTYLAMINE CHEMBRDG-BB 4005902 2-CYCLOOCTYL-ETHYLAMINE 4-PIPERIDIN-1-YL-BUTAN-1-OL 3-DIMETHYLAMINO-2,2-DIMETHYL-1-PROPANOL (1-PHENYLCYCLOPENTYL)METHYLAMINE 3-(DIBUTYLAMINO)-1-PROPANOL 4-PHENYL-AZEPANE HCL CHEMBRDG-BB 4013122 N-PHENYL-3-PIPERIDINAMINE AZEPAN-3-YL-METHYL-AMINE