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| | trans-Dichlorodiamineplatinum(II) Basic information |
| | trans-Dichlorodiamineplatinum(II) Chemical Properties |
| Melting point | 340 °C (dec.)(lit.) | | storage temp. | 2-8°C | | solubility | DMSO (Sparingly) | | form | crystalline | | color | yellow | | Water Solubility | Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water. | | Exposure limits | ACGIH: TWA 0.002 mg/m3
NIOSH: IDLH 4 mg/m3; TWA 0.002 mg/m3 | | EPA Substance Registry System | Platinum, diamminedichloro-, (SP-4-1)- (14913-33-8) |
| | trans-Dichlorodiamineplatinum(II) Usage And Synthesis |
| Chemical Properties | Yellow Powder or Crystal | | Uses | Transplatin is the trans stereoisomer impurity of trans-Dichlorodiamineplatinum(II), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer. | | Uses | Transplatin is the trans stereoisomer impurity of Cisplatin (C499500), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer. | | Definition | ChEBI: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a trans planar configuration around the central platinum ion. Unlike its cis-isomer, cisplatin, it does not exhibit
any useful pharmacological effect and is toxic. | | Safety Profile | Poison by
intraperitoneal route. Questionable
carcinogen with experimental tumorigenic
data. Human mutation data reported. See
also PLATINUM COMPOUNDS. When
heated to decomposition it emits toxic
fumes of NOx and Cl-. |
| | trans-Dichlorodiamineplatinum(II) Preparation Products And Raw materials |
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