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| | CP 376395 Basic information |
| Product Name: | CP 376395 | | Synonyms: | CP 376395;CP 376395 hydrochloride;N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinaminehydrochloride;CP376395;CP-376395;CP 376395;4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-;inhibit,CP376395,Inhibitor,Corticotropin-releasing Factor Receptor,CRFR,CP 376395,CP-376395 | | CAS: | 175140-00-8 | | MF: | C21H30N2O | | MW: | 326.48 | | EINECS: | | | Product Categories: | | | Mol File: | 175140-00-8.mol |  |
| | CP 376395 Chemical Properties |
| Melting point | 224 °C | | Boiling point | 434.9±45.0 °C(Predicted) | | density | 1.018±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at RT | | solubility | DMF: 30 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml | | form | A crystalline solid | | pka | 7.23±0.48(Predicted) |
| | CP 376395 Usage And Synthesis |
| Biological Activity | Potent and selective CRF 1 receptor antagonist (K i values are 12 and >10000 nM for CRF 1 and CRF 2 receptors respectively). Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active. |
| | CP 376395 Preparation Products And Raw materials |
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