1,12-Bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecane dibromide

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1,12-Bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecane dibromide Basic information
Product Name:1,12-Bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecane dibromide
Synonyms:1,12-Bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecane dibromide;SAR 97276;AlbitiazoliuM broMide;2-[3-[12-[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]dodecyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol:dibromide
CAS:321915-72-4
MF:C24H42Br2N2O2S2
MW:614.54
EINECS:
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Mol File:321915-72-4.mol
1,12-Bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecane dibromide Structure
1,12-Bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecane dibromide Chemical Properties
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1,12-Bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecane dibromide Usage And Synthesis
UsesSAR 97276 (Albitiazolium bromide) is an antimalarial agent. SAR 97276 interfers with the phospholipid metabolism of malarial parasites, especially the biosynthesis of phosphatidylcholine (PC). SAR 97276 enters erythrocytes through the new permeability pathways (NPP) of infected erythrocytes, and is transported into the malarial parasite by a poly-specific cation carrier[1].
References[1] Wein S, et al., Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate. Br J Pharmacol. 2012 Aug;166(8):2263-76. DOI:10.1111/j.1476-5381.2012.01966.x
1,12-Bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecane dibromide Preparation Products And Raw materials
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