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Besifloxacin hydrochloride

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Products Intro: Product Name:Besifloxacin hydrochloride (405165-61-9)
CAS:405165-61-9
Purity:99% Package:10G;10USD
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Products Intro: Product Name:Besifloxacin hydrochloride
CAS:405165-61-9
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Products Intro: Product Name:Besifloxacin hydrochloride
CAS:405165-61-9
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Products Intro: Product Name:Besifloxacin hydrochloride
CAS:405165-61-9
Purity:99% Package:5KG;1KG

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Besifloxacin hydrochloride Basic information
Outline Besifloxacin hydrochloride ophthalmic suspension
Product Name:Besifloxacin hydrochloride
Synonyms:Besifloxacin HCl;Unii-7506A6J57t;(R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride;Besifloxacin hydrochloride;(R)-7-(3-AMinohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinolin-3-carboxylic acid HCl;3-Quinolinecarboxylic acid, 7-[(3R)-3-aMinohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride (9CI);(R)-7-(3-aMinoazepan-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;7-[(3R)-3-AMinohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Hydrochloride
CAS:405165-61-9
MF:C19H21ClFN3O3.ClH
MW:430.305
EINECS:1312995-182-4
Product Categories:Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;API
Mol File:405165-61-9.mol
Besifloxacin hydrochloride Structure
Besifloxacin hydrochloride Chemical Properties
Melting point >210°C (dec.)
storage temp. Refrigerator
Safety Information
MSDS Information
Besifloxacin hydrochloride Usage And Synthesis
OutlineBesifloxacin hydrochloride is developed by Bausch & Lomba as a new type of fluoroquinolones for the treatment of bacterial conjunctivitis (a non-viral caused infectious purulent eye irritation conjunctivitis ). Bacterial conjunctivitis which is a contagious eye disease, is a common disease that affects people of all ages. The clinical symptoms of infested eye including: foreign body sensation, burning sensation, tearing; conjunctival hyperemia, mucus or purulent discharge; eyelid edema, conjunctival edema and subconjunctival hemorrhage may occur in severe cases .
Besifloxacin hydrochloride ophthalmic suspensionBesifloxacin hydrochloride ophthalmic suspension (Besivance) is a fluoroquinolone drug recently approved for the topical treatment of bacterial conjunctivitis. This medicine can quickly kill common pathogens causing conjunctivitis , that is coagulase-negative staphylococci, Streptococcus pneumoniae, Staphylococcus aureus , Haemophilus influenzae bacteria, and other less common bacteria.. Besifloxacin is an effective drug to the Gram-positive and Gram-negative pathogens, include other fluoroquinolone-resistant bacteria , also it can balance the DNA gyrase and topoisomerase IV activity, slow the development of resistance. Topical administration can achieve stable and lasting high concentrations in human tears , and penetration in animal ocular tissue is good, showing excellent safety.
Pharmacokinetic and pharmacodynamic characteristics of Besifloxacin meet the criteria for successfully clearing most Gram-positive and Gram-negative bacteria, while exhibiting minimal systemic exposure.Besifloxacin biochemical properties, pharmacokinetics targeted to achieve/pharmacodynamic objectives and limited to local ophthalmic drug will slow the development of bacterial resistance, making Besifloxacin become attractive choice for acute bacterial conjunctivitis treatment.
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesPale Yellow Solid
UsesBesifloxacin HCl is a fourth-generation fluoroquinolone antibiotic
UsesA Fluoroquinolone antibiotic.
Besifloxacin hydrochloride Preparation Products And Raw materials
Tag:Besifloxacin hydrochloride(405165-61-9) Related Product Information
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