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SteMRegenin 1

SteMRegenin 1 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:SetmEegenin 1
CAS:1227633-49-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:SteMRegenin 1
CAS:1227633-49-9
Purity:99% Package:1kg;2USD
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:StemRegenin 1
CAS:1227633-49-9
Purity:>98% Package:100mg Remarks:BOC Sciences also provides custom synthesis services for StemRegenin 1.
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Products Intro: Product Name:SteMRegenin 1
CAS:1227633-49-9
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-87569265 +86-18612256290
Email: 1056@dideu.com
Products Intro: Product Name:SteMRegenin 1
CAS:1227633-49-9
Purity:99% Package:5mg;USD|100mg;USD|10g;USD|500g;USD|25KG;USD

SteMRegenin 1 manufacturers

  • SteMRegenin 1
  • SteMRegenin 1 pictures
  • $0.00 / 5mg
  • 2021-07-20
  • CAS:1227633-49-9
  • Min. Order: 5mg
  • Purity: 99%
  • Supply Ability: 2000tons
  • SteMRegenin 1
  • SteMRegenin 1 pictures
  • $2.00 / 1kg
  • 2019-07-06
  • CAS:1227633-49-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
  • SteMRegenin 1
  • SteMRegenin 1 pictures
  • $2.00 / 1kg
  • 2019-07-06
  • CAS:1227633-49-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
SteMRegenin 1 Basic information
Product Name:SteMRegenin 1
Synonyms:Novartis SR1;SteMRegenin 1 (SR1);SetMEegenin 1;4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol;SetmRegenin 1;4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol StemRegenin 1;SteMRegenin 1 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol;SteMRegenin 1
CAS:1227633-49-9
MF:C24H23N5OS
MW:429.54
EINECS:
Product Categories:Antineoplastic;apis;Inhibitors
Mol File:1227633-49-9.mol
SteMRegenin 1 Structure
SteMRegenin 1 Chemical Properties
Boiling point 604.9±65.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility Soluble in DMSO (up to 10 mg/ml).
form White solid
pka10.03±0.15(Predicted)
color Off-white
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKeyBGFHMYJZJZLMHW-UHFFFAOYSA-N
Safety Information
Hazard Codes Xn
Risk Statements 22
HS Code 2934999090
MSDS Information
SteMRegenin 1 Usage And Synthesis
DescriptionSR1 (1227633-49-9)?extends the pluripotency of hematopoietic stem cells by antagonizing the arylhydrocarbon receptor (AhR), IC50?= 127?nM.1?The effect is dose-dependent and reversible. Displays a biphasic effect on CD34-negative cells with low does (1 μM) enhancing proliferation and high does (>5 μM) repressing proliferation.2?May be used to generate progenitor T cells3?from HSPCs as well as NK cells for immuno-oncology studies4.
ApplicationStemRegenin 1 can also be used to treat infectious diseases such as HIV/AIDS, malaria, and tuberculosis. The mechanism by which StemRegenin 1 stimulates the production of new red blood cells is not well understood; however, it appears to work through activation of JAK1. This protein inhibits the polymerase chain reaction (PCR), which is an enzyme that increases the rate at which DNA copies are made from a template molecule. Inhibitors of this enzyme have been shown to prevent infection with Human Immunodeficiency Virus (HIV) in vitro.
General DescriptionA cell-permeable purine compound that acts as a high affinity AhR antagonist (IC50 = 127 nM against 3 nM TCDD-induced luciferase reporter activity in HepG2 cultures), but not a panel of 61 kinases. AhR expression and function knockouts by shRNAs, CH-223191 (Cat. No. 182705), or SR1 treatment all result in enhanced and sustained CD34+ population in long-term proliferating/expanding cultures of cord blood-derived HSCs (hematopoietic setem cells) in serum-free media containing Tpo (Cat. No. 605218), SCF (Cat. No. 569600), Flt3 Ligand (Cat. No. 343010), and IL-6 (Cat. No. 407652) in a reversible manner. SR1 is reactive toward human, monkey, and canine, but not rat or murine, species.
UsesStemRegenin 1 is a plant-derived stem cell factor that is potent inducers of hematopoietic stem cells. It has been shown to stimulate the differentiation and proliferation of primary cells, such as human umbilical cord blood cells and bone marrow cells, into mature erythrocytes and leukocytes.
targetAhR
storageStore at -20°C
References1) Boitano?et al.?(2010),?Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells; Science,?329?1354 2) Tao?et al.?(2017),?StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells; J. Stem Cells Regen. Med.,?13?75 3) Singh?et al.?(2019),?Generation and function of progenitor T cells from stemRegenin-1-expanded CD34+ human hematopoietic progenitor cells;?Blood Adv,?3?2934 4) Hoogstad-van Evert?et al.?(2017),?Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull?mice; Oncoimmunology,?6(8)?e1320630
SteMRegenin 1 Preparation Products And Raw materials
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