|
|
| | SPD-304 Basic information |
| Product Name: | SPD-304 | | Synonyms: | SPD-304;CAY10500;6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;SPD-304 Exclusive;CS-2594;4H-1-Benzopyran-4-one, 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-;TNF Receptor,Tumor Necrosis Factor Receptor,inhibit,SPD-304,SPD 304,SPD304,Inhibitor,TNFR;6,7-Dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-3-indolyl]methyl]amino]ethyl]amino]methyl]-4H-chromen-4-one | | CAS: | 869998-49-2 | | MF: | C32H32F3N3O2 | | MW: | 547.61 | | EINECS: | | | Product Categories: | | | Mol File: | 869998-49-2.mol |  |
| | SPD-304 Chemical Properties |
| Boiling point | 589.2±50.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 1 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml | | form | A crystalline solid | | pka | 7.65±0.50(Predicted) |
| | SPD-304 Usage And Synthesis |
| Uses | SPD304 has been used in the inhibition of tumor necrosis factor receptor 1 (TNFR1) in dorsal root ganglion neurons and tumor necrosis factor alpha in colonic epithelial cell lines. | | Biochem/physiol Actions | SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM. |
| | SPD-304 Preparation Products And Raw materials |
|