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| | Ubiquitin E1 Inhibitor, PYR-41 Basic information |
| | Ubiquitin E1 Inhibitor, PYR-41 Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: 10mg/mL | | form | solid | | color | dark purple |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | Ubiquitin E1 Inhibitor, PYR-41 Usage And Synthesis |
| Uses | A cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50<10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation. |
| | Ubiquitin E1 Inhibitor, PYR-41 Preparation Products And Raw materials |
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