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Product Name:1-[[3-Fluoro-4-[5-[(2-fluorophenyl)Methyl]-2-benzothiazolyl]phenyl]Methyl]-3-azetidinecarboxylic Acid
CAS:1257093-40-5
Package:100Mg,10Mg,50Mg
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Shanghai TaoSu Biochemical Technology Co., Ltd.
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Product Name:1-[[3-Fluoro-4-[5-[(2-fluorophenyl)Methyl]-2-benzothiazolyl]phenyl]Methyl]-3-azetidinecarboxylic Acid
CAS:1257093-40-5
Purity:90% Package:10Mg;50Mg;100Mg;
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EMMX Biotechnology LLC
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888-539-0666 |
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Product Name:TC-SP 14
CAS:1257093-40-5
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 13028896684 |
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sales@rrkchem.com |
| Products Intro: |
Product Name:1-[[3-Fluoro-4-[5-[(2-fluorophenyl)Methyl]-2-benzothiazolyl]phenyl]Methyl]-3-azetidinecarboxylic Acid
CAS:1257093-40-5
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| | TC-SP 14 Basic information |
| | TC-SP 14 Chemical Properties |
| Boiling point | 608.1±65.0 °C(Predicted) | | density | 1.396±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at RT | | solubility | <22.52mg/ml in DMSO | | form | solid | | pka | 2.65±0.20(Predicted) | | color | Off-white |
| | TC-SP 14 Usage And Synthesis |
| Uses | 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic Acid is a potent Sphingosine-1-Phosphate Receptor 1 (S1P1) agonist with minimal activity at S1P3. It has been shown to attenuate DTH response to antigen challenge while significantly reducing blood lymphocyte counts. | | Biological Activity | ec50: 0.042 μm for hs1p1tc-sp 14 is an agonist of sphingosine-1-phosphate receptor 1 (s1p1).studies have revealed that the lysophospholipid sphingosine-1-phosphate (s1p1) is a pleiotropic modulator of diverse cellular processes. such effects are reported to be mediated by the interactions of s1p with a set of paralogous g proteincoupled receptors, which are widely expressed in the immune, central nervous and cardiovascular systems. | | in vitro | as a small lipophilic substituent proved equally effective to a larger substituent in reducing s1p3 activity, tc-sp 14 was screened. tc-sp 14 was found to be a potent s1p1 agonist (ec50 = 0.042 μm) with reduced activity for s1p3 (ec50 = 3.47 μm) [1]. | | in vivo | in lewis rats, tc-sp 14 produced a dose-dependent reduction in circulating blood lymphocytes, which was consistent with s1p1 agonism. moreover, statistical significance was shown at a dose of 0.3 mg/kg, and the dose fo 3.0 mg/kg led to near maximal lymphopenia. tc-sp 14 was subsequently investigated in a dth antigen challenge model. results showed a statistically significant reduction in ear swelling at doses of 0.3 mg/kg and higher. in addition, reduced ear swelling was found to closely track circulating lymphocyte counts [1]. | | references | [1] lanman ba,cee vj,cheruku sr et al. discovery of a potent, s1p3-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (s1p1). acs med chem lett.2010 nov 9;2(2):102-6. |
| | TC-SP 14 Preparation Products And Raw materials |
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