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| | L778123 Basic information |
| Product Name: | L778123 | | Synonyms: | L-778123HCl;L-778123 (hydrochloride);4-[[5-[[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]benzonitrile monohydrochloride;L778123; L-778123; L 778123; L778,123; L-778,123; L 778,123 HCL; L-778123 HYDROCHLORIDE;4-((5-((4-(3-Chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride;4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile,hydrochloride;L-778123;L 778123;L778123;L-778123 hydrochloride (L-778,123 hydrochloride) | | CAS: | 253863-00-2 | | MF: | C22H21Cl2N5O | | MW: | 442.34104 | | EINECS: | | | Product Categories: | API | | Mol File: | 253863-00-2.mol |  |
| | L778123 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 12.5 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid |
| | L778123 Usage And Synthesis |
| Definition | ChEBI: L-778,123 hydrochloride is the hydrochloride salt of L-778,123. It is a dual inhibitor of FPTase and GGPTase-I (IC50 of 2nM and 98nm, respectively) and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor, an EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor and a radiosensitizing agent. It contains a L-778,123 (free base). |
| | L778123 Preparation Products And Raw materials |
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