L778123

L778123 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:253863-00-2
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:L-778123 HCl
CAS:253863-00-2
Purity:98% Package:50 mg Remarks:Reach out to us for more information about custom solutions.
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:4-((5-((4-(3-Chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride
CAS:253863-00-2
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-27213
Company Name: TopScience Biochemical
Tel: 00852-68527855
Email: info@itopbiochem.com
Products Intro: Product Name:L-778123 hydrochloride
Purity:99.9% Package:1g;USD|50g;USD
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name:4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile,hydrochloride
CAS:253863-00-2
Purity:Min98% HPLC Package:1KG;1USD

L778123 manufacturers

L778123 Basic information
Product Name:L778123
Synonyms:L-778123HCl;L-778123 (hydrochloride);4-[[5-[[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]benzonitrile monohydrochloride;L778123; L-778123; L 778123; L778,123; L-778,123; L 778,123 HCL; L-778123 HYDROCHLORIDE;4-((5-((4-(3-Chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride;4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile,hydrochloride;L-778123;L 778123;L778123;L-778123 hydrochloride (L-778,123 hydrochloride)
CAS:253863-00-2
MF:C22H21Cl2N5O
MW:442.34104
EINECS:
Product Categories:API
Mol File:253863-00-2.mol
L778123 Structure
L778123 Chemical Properties
storage temp. Store at -20°C
solubility DMF: 12.5 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 10 mg/ml
form A crystalline solid
color White to off-white
Safety Information
MSDS Information
L778123 Usage And Synthesis
UsesL-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I, with IC50 values of 2 nM and 98 nM respectively.
DefinitionChEBI: L-778,123 hydrochloride is the hydrochloride salt of L-778,123. It is a dual inhibitor of FPTase and GGPTase-I (IC50 of 2nM and 98nm, respectively) and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor, an EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor and a radiosensitizing agent. It contains a L-778,123 (free base).
in vivo

L-778123 (50 mg/kg/day, infusion, 7 days) hydrochloride inhibits both HDJ2 and Rap1A prenylation in PBMCs of dogs, but without inhibition in Ki-Ras prenylation[1].

References[1] Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758. PMID:12479371
[2] Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77. DOI:10.5681/apb.2013.012
[3] Fredrick O. Onono, et al. The Farnesyltransferase Inhibitor (FTI) L-778,123 Displays Promising Anti-Leukemia Activity. Blood (2008); 112 (11): 2627.
[4] Si MS, et al. Inhibition of lymphocyte activation and function by the prenylation inhibitor L-778,123. Invest New Drugs. 2005 Jan;23(1):21-9. DOI:10.1023/B:DRUG.0000047102.26698.08
L778123 Preparation Products And Raw materials
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