ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Ubiquitin >E2 conjugating inhibitors >NSC697923

NSC697923

NSC697923 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:NSC697923
CAS:343351-67-7
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:NSC697923
CAS:343351-67-7
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:NSC697923
CAS:343351-67-7
Purity:98% Package:5mg Remarks:V1317
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:NSC697923
CAS:343351-67-7
Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054
Email: trendseenbio@gmail.com
Products Intro: Product Name:NSC697923
CAS:343351-67-7
Purity:99% Package:1kg;25kg
NSC697923 Basic information
Product Name:NSC697923
Synonyms:Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-;NSC697923;2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran;2-Nitro-5-tosylfuran;2-Nitro-5-(toluene-4-sulfonyl)-furan;2-[(4-Methylphenyl)sulfonyl]-5-nitrofur;NSC697923 USP/EP/BP
CAS:343351-67-7
MF:C11H9NO5S
MW:267.25786
EINECS:
Product Categories:Inhibitors
Mol File:343351-67-7.mol
NSC697923 Structure
NSC697923 Chemical Properties
Melting point 124-126°C
Boiling point 443.8±40.0 °C(Predicted)
density 1.416±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO: soluble20mg/mL, clear
form powder
color white to beige
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26-39
WGK Germany 3
MSDS Information
NSC697923 Usage And Synthesis
DescriptionNSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1?Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3?Induces neuroblastoma cell death via activation of p53 and JNK.4
UsesNSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).
storage+4°C
References1) Pulvino et al.?(2012),?Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood,?120?1668 2) Strickson?et al.?(2013),?The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system; Biochem. J.,?451?427 3) Hodge?et al.?(2015),?Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol.,?10?1718 4) Cheng?et al.?(2014),?A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis.,?5?e1079
NSC697923 Preparation Products And Raw materials
Tag:NSC697923(343351-67-7) Related Product Information
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