6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐 CAS#: 174634-09-4

6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐

生物活性靶点体外研究体内研究用途与合成方法 MSDS 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐价格(试剂级) 上下游产品信息

中文名称	6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐
中文同义词	6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐;拓扑异构酶I和II抑制剂(TAS-103双盐酸盐);TAS-103(BMS-247615)盐;TAS-103双盐酸盐;化合物TAS-103 (DIHYDROCHLORIDE)
英文名称	TAS 103
英文同义词	TAS-103 (dihydrochloride);TAS-103(2HCl);TAS-103(BMS-247615);6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride;BMS-247615-2HCl;BMS 247615 dihydrochloride;BMS247615 dihydrochloride;BMS-247615 dihydrochloride
CAS号	174634-09-4
分子式	C20H21Cl2N3O2
分子量	406.30564
EINECS号
相关类别	细胞生物学试剂
Mol文件	174634-09-4.mol
结构式

6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐性质

储存条件	under inert gas (nitrogen or Argon) at 2-8°C
溶解度	PBS (pH 7.2):1.0(最大浓度 mg/mL);2.46(最大浓度 mM)
形态	结晶固体

6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐用途与合成方法

生物活性

TAS-103 dihydrochloride 是一种 DNA 拓扑异构酶 I/II (topoisomerase I/II) 双重抑制剂，可用于癌症研究。

靶点

Topoisomerase I

Topoisomerase II

体外研究

TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC ₅₀ value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC ₅₀ of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation.

体内研究

TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.

安全信息

MSDS信息

6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/01/25	HY-13758A	TAS-103 dihydrochloride		1 mg	500元
2024/01/25	HY-13758A	6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐 TAS-103 dihydrochloride	174634-09-4	5mg	1100元

6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐