3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester

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Products Intro: Product Name:WDR5 0103
CAS:890190-22-4
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Products Intro: Product Name:3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
CAS:890190-22-4
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Products Intro: Product Name:WDR5-0103
CAS:890190-22-4
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CAS:890190-22-4
Purity:99% Package:5KG;1KG Remarks:WDR5 0103
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Products Intro: Product Name:WDR5-0103
CAS:890190-22-4
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3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Basic information
Product Name:3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
Synonyms:3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester;Methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate;WDR5-0103;WDR50103, >98%;WD-Repeat Protein 5-0103;WD-REPEAT PROTEIN 5-0103;WDR5 0103;WDR50103;Benzoic acid, 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-, methyl ester;WDR5(WDR5-0103)
CAS:890190-22-4
MF:C21H25N3O4
MW:383.44
EINECS:
Product Categories:Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:890190-22-4.mol
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Structure
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Chemical Properties
Boiling point 495.2±45.0 °C(Predicted)
density 1.223±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: soluble10mg/mL, clear
form powder
pka12.96±0.70(Predicted)
color white to beige
Safety Information
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
MSDS Information
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Usage And Synthesis
DescriptionWD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3. WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones. WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 μM).
Uses3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic Acid Methyl Ester is an small molecule inhibitor of WDR5, an essential componet of the human trithorax-like famliy of SET1 methyltransferase complexes that carry out trimethylation of histone 3 Lys4.
storageStore at +4°C
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Preparation Products And Raw materials
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