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Chlorosulfonic acid

Chlorosulfonic acid Basic information
Product Name:Chlorosulfonic acid
Synonyms:acidechlorosulfonique;chlorosulfonic;Chloridosulfuric acid;Sulfric chlorohydrin;Sulfuric acidchloride;Chlorosulfonic acid,98%;Monochlorosulfonic acid;Sulfuric acidchlorohydrin
Product Categories:Miscellaneous Reagents;TLC Visualization Reagents (alphabetic sort);Pharmaceutical Intermediates;Inorganics;GlycosidesChemical Synthesis;TLC Visualization Reagents (by application);Inorganic AcidsDerivatization Reagents TLC;Steroids, Terpenes, Lipids, Bile acidsDerivatization Reagents TLC;Derivatization Reagents TLC;Synthetic Reagents;TLC Reagents, A-C
Mol File:7790-94-5.mol
Chlorosulfonic acid Structure
Chlorosulfonic acid Chemical Properties
Melting point -80°C
Boiling point 151-152 °C755 mm Hg(lit.)
density 1.753 g/mL at 25 °C(lit.)
vapor density 4 (vs air)
vapor pressure 1 mm Hg ( 25 °C)
refractive index n20/D 1.433(lit.)
Fp 158°C
solubility Miscible with hydrocarbons.
form Oily Liquid, Fuming In Air
color Yellow to brown
Specific Gravity1.753
PH Range1
Water Solubility reacts
Sensitive Moisture Sensitive
Merck 14,2165
Stability:Stable, but reacts violently with water. In case of spills, mop up with sand - do not add water. Reacts with most metals to yield (flammable) hydrogen gas. Incompatible with strong bases, carbonates, water, combustible materials, strong oxidizing agents, most metals, organic materials, sulfides, cyanides, carbides.
CAS DataBase Reference7790-94-5(CAS DataBase Reference)
EPA Substance Registry SystemChlorosulfonic acid (7790-94-5)
Safety Information
Hazard Codes C
Risk Statements 14-35-37
Safety Statements 26-45
RIDADR UN 1754 8/PG 1
WGK Germany 1
RTECS FX5730000
HazardClass 8
PackingGroup I
HS Code 28062000
Hazardous Substances Data7790-94-5(Hazardous Substances Data)
MSDS Information
SigmaAldrich English
ALFA English
Chlorosulfonic acid Usage And Synthesis
Chemical PropertiesChlorosulfonic acid, ClS03H, also known as chlorosulfuric acid and sulfuric chlorohydrin, is an colorless to light yellow oily liquid. It is formed from sulfur trioxide and hydrogen chloride, but decomposes in water to form hydrochloric acid and sulfuric acid.It is a vigorous dehydrating agent and is used in manufacturing synthetic drugs,poison gas, and saccharin.
Chemical PropertiesChlorosulfonic acid is a highly corrosive, colorless to yellow, slightly cloudy, fuming liquid with a sharp odor.
UsesChlorosulfuric Acid is used in the preparation of benzothiazepinylphosphonate bile acid transporter inhibitor. Also used in the preparation ofsulfated guar gum for potential use as an antioxidant.
Usesmanufacture of sulfone Compounds, saccharin. As chlorosulfonating and condensing agent in organic syntheses.
General DescriptionA colorless to yellow colored fuming liquid with a pungent odor. Density 14.7 lb / gal. Causes severe burns. Very toxic by inhalation. Corrosive to metals.
Reactivity ProfileChlorosulfonic acid is a strong oxidizing acid. Reacts violently with water, strong mineral acids and bases, alcohols, finely dispersed organic matter. Dangerously incompatible with combustible materials, nitrates, chlorates, metallic powders, carbides, picrates, and fulminates. Undergoes possibly violent reactions with acetic acid, acetic anhydride, acetonitrile, acrolein, acrylic acid, acrylonitrile, alkali, allyl alcohol, allyl chloride, ammonium hydroxide, aniline, butyraldehyde, cresol, cumene, diethyleneglycol methyl ether, diisopropyl ether, diphenyl ether, ethyl acetate, ethyl acrylate, ethylene chlorohydrin, ethylenediamine, ethylene glycol, glyoxal, hydrocarbons (hexane, heptane), hydrogen peroxide, isoprene, powdered metals, methyl ethyl ketone, propylene oxide, vinyl acetate. When heated to decomposition, Chlorosulfonic acid emits toxic fumes of hydrogen chloride and oxides of sulfur [Sax, 9th ed., 1996, p. 831]. Reaction with phosphorus accelerates out of control and culminates in an explosion [Heumann, K. et al., Ber., 1882, 15, p. 417]. Mixing chlorosulfuric acid and 98% sulfuric acid may evolve HCl [Subref: Anon, Loss Prev. Bull. 1977, (013), 2-3].
HazardToxic by inhalation; strong irritant to eyes and skin; causes severe burns. Can ignite combustible materials. Evolves hydrogen on contact with most metals.
Health HazardINHALATION: vapor extremely irritating to lungs and mucous membranes. Vapor has such a sharp and pentrating odor that inhalation of severely toxic quantities is unlikely unless it is impossible to escape the fumes. CONTACT WITH EYES OR SKIN: liquid acid will severely burn body tissue.
Safety ProfileA poison irritant. See also SULFURIC ACID. Chlorosulfonic acid is corrosive, can cause severe acid burns and is very irritating to the eyes, lungs, and mucous membranes. It can cause acute toxic effects either in the liquid or vapor state. Inhalation of concentrated vapor may cause loss of consciousness with serious damage to lung tissue. Contact of liquid with the eyes can cause severe burns if the liquid is not immediately and completely removed. It also causes severe sh burns due to its highly corrosive action. Upon ingestion it
Potential ExposureUsed to make pesticides, detergents, pharmaceuticals, dyes, resins, sulfonated oils; intermediate for dyes and pharmaceuticals; and pesticides. Although no military designation has been assigned chlorosulfonic acid may have been used as a choking/pulmonary agent
ShippingUN1754 Chlorosulfonic acid (with or without sulfur trioxide), Hazard class: 8; Labels: 8-Corrosive material, 6.1-Poison Inhalation Hazard, Inhalation Hazard Zone B.
Purification MethodsDistil the acid in an all-glass apparatus, taking the fraction boiling at 156-158o. It reacts EXPLOSIVELY with water [Cremlyn Chlorosulfonic acid: A Versatile Reagent, Royal Society of Chemistry UK, 2002, p 308, ISBN 0854044981, Fehér in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 385 1963].
IncompatibilitiesExplosively reacts with water, forming sulfuric and hydrochloric acid and dense fumes. Dangerously reactive, avoid contact with all other material. Violent reaction with many compounds, including reducing agents; alcohols, chemically active metals; combustible materials, strong acids, alkaline earth sulfides, aluminum carbides, aluminum, amines, calcium sulfide, carbides, chlorine trifluoride, glycerin, hydrides, hydrochloric acid, hydrogen peroxide, hydrogen sulfide, hydroxylamine, magnesium, metal powders, metal sulfides, molybdenum, phenylhydrazine, phosphorous red/friction, phosphorous trichloride, silicon, sulfides, sulfur, sulfur dioxide, sulfur/ friction, sulfuric acid, tungsten, hydrogen trisulfide, diphenyl ether, finely divided metals, silver nitrate. Contact with phosphorous may cause fire and explosions. Forms explosive material with ethyl alcohol. Attacks many metals; reaction with steel drums forms explosive hydrogen gas, which must be periodically relieved.
Chlorosulfonic acid Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Chloroform-->Chlorine-->Hydrogen-->Sulfur-->Sulfur dioxide-->Sulphur-->Sulfur trioxide-->Sulfur dichloride-->PYRITE
Preparation Products2-Thiophenesulfonyl chloride-->Sodium lauryl polyoxyethylene ether sulfate-->4-Chlorobenzenesulfonamide-->4-(Acetamidomethyl)benzenesulfonylchloride-->Tetradifon-->2-[(4-Aminophenyl)sulfonyl]ethyl hydrogen sulfate-->4-(TRIMETHYL-UREIDO)-BENZENESULFONYL CHLORIDE-->5-CHLORO-4-NITROTHIOPHENE-2-SULFONYL CHLORIDE-->METHYL 3-(4-CHLOROSULFONYL)PHENYLPROPIONATE-->2,5-Dichlorothiophene-3-sulfonamide-->4-BIPHENYLSULFONYL CHLORIDE-->2,4-Dichlorobenzenesulfonyl chloride-->2,4,6-TRIFLUOROBENZENESULFONYL CHLORIDE-->2,4,5,6-TETRAMETHYLBENZENEDISULFONYL DICHLORIDE-->2,4-Dichloro-5-sulfamoylbenzoic acid-->Disperse Yellow Se-Fl-->5-[(ACETYLAMINO)METHYL]THIOPHENE-2-SULFONYL CHLORIDE-->2-Amino-4-chloropyrimidine-->2,4-MESITYLENEDISULFONYL DICHLORIDE-->BENZO[1,3]DIOXOLE-5-SULFONYL CHLORIDE-->5-Chlorothiophene-2-sulfonyl chloride-->PYRROLIDINE-1-SULFONYL CHLORIDE-->Indigosol Green Blue IBC-->Cyclamic acid-->2,3,4,5-Tetrachloronitrobenzene-->OVEX-->4-(AMINOMETHYL)BENZENESULFONAMIDE-->3,5-DIMETHYLISOXAZOLE-4-SULFONYL CHLORIDE-->2-(Chloromethyl)-1-methyl-4-nitrobenzene-->Methyl benzenesulfonate-->SULFUR TRIOXIDE TRIMETHYLAMINE COMPLEX-->4,5-Dibromothiophene-2-sulphonyl chloride-->Sulfenone-->sodium (3,6or3,7)-bis(1,1-dimethylethyl)naphthalene-1-sulphonate-->N-[(3a,5b,7a)-7-hydroxy-24-oxo-3-(sulfooxy)cholan-24-yl]-glycine
Tag:Chlorosulfonic acid(7790-94-5) Related Product Information
Thionyl chloride 2-BENZOYLACETANILIDE CHLOROSULFONIC ACID BY R.J. CREMLYN Chlorosulfonic acid propyl ester Methylene bis-(chlorosulfate) (MBCS) Diacetonefructose chlorosulfate Methyl chlorosulfonate CHLOROSULFONIC ACID TRIFLUOROVINYL ESTER ETHYL CHLOROSULFONATE Chlorosulfonic acid (trimethylsilyl) ester,Chlorosulfonic acid trimethylsilyl ester PYROSULFURYL CHLORIDE Chlorosulfonic acid Chloromethyl chlorosulfate Ethyl 2-(Chlorosulfonyl)acetate Ascoric Acid phosphoric acid Citric acid Glycine