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D-TUBOCURARINE CHLORIDE

D-TUBOCURARINE CHLORIDE Basic information
Product Name:D-TUBOCURARINE CHLORIDE
Synonyms:(+)-tubocurarinehydrochloride;amerizol;d-tubocurarinehydrochloride;intocostrin;intocostrinet;tubadil;tubarine;tubocurarinehydrochloride
CAS:57-94-3
MF:C37H42Cl2N2O6
MW:681.65
EINECS:200-356-9
Product Categories:Organics;AntagonistsIon Channels;Cholinergics;Ligand-Gated Ion Channels;Neurotransmitters;Nicotinic Acetylcholine Receptor Modulators;Acetylcholine receptor;Nicotinic
Mol File:57-94-3.mol
D-TUBOCURARINE CHLORIDE Structure
D-TUBOCURARINE CHLORIDE Chemical Properties
Melting point 274~275℃
alpha D20-25 +215° (c = 0.25-0.3 g/100 ml)
density 1.2074 (rough estimate)
refractive index 1.7350 (estimate)
storage temp. 2-8°C
pkapK: 7.4(at 25℃)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 1544 6.1/PG 2
WGK Germany 3
RTECS YO4900000
HazardClass 6.1(b)
PackingGroup III
ToxicityLD50 in mice, rats (mg/kg): 33.2, 27.8 orally in DMSO; 59.5, 36.9 orally in water (Rosen)
MSDS Information
ProviderLanguage
SigmaAldrich English
D-TUBOCURARINE CHLORIDE Usage And Synthesis
Chemical PropertiesWhite to light-tan crystalline alkaloid; odorless. Mp 270C with decomposition. Soluble in water and alcohol; insoluble in acetone, chloroform, and ether; aqueous solution is strongly dextrorotatory (specific rotation for 1% solution of anhydrous ?208 to +218 degrees).
UsesNeuromuscular blocking agent.
HazardHighly toxic.
Biological ActivityCompetitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT 3 and GABA A receptor antagonist.
Safety ProfilePoison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human toxicity: Large doses and overdoses may cause respiratory paralysis and hypotension. When heated to decomposition it emits very toxic fumes of NOx and Cl-. Used as a muscle relaxant.
Purification MethodsCrystallise this chloride from water. It forms various hydrates. The hydrochloride pentahydrate has m 268-269o (from H2O) and [] D +190o (0.5, H2O). Its solubility in H2O at 25o is 50mg/mL. [Beilstein 27 II 897, 27 III/IV 8727.]
D-TUBOCURARINE CHLORIDE Preparation Products And Raw materials
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