| Company Name: |
Chengdu Senior Pharma Technology Co.Ltd. Gold
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| Tel: |
+86-0838-2319818 +86-15982001943 |
| Email: |
seniorpharma@163.com |
| Products Intro: |
Product Name:Sappanone A
CAS:102067-84-5
Purity:97% Package:100mg;200mg;500mg
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| | Sappanone A Basic information |
| Product Name: | Sappanone A | | Synonyms: | Sappanone A;3-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one;(E)-7-hydroxy-3-[(3,4-dihydroxyphenyl)methylene]-chroman-4-one;3-(3,4-Dihydroxybenzylidene)-7-hydroxychroman-4-one;4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy- | | CAS: | 102067-84-5 | | MF: | C16H12O5 | | MW: | 284.26 | | EINECS: | | | Product Categories: | | | Mol File: | 102067-84-5.mol |  |
| | Sappanone A Chemical Properties |
| Boiling point | 605.5±55.0 °C(Predicted) | | density | 1.521±0.06 g/cm3(Predicted) | | solubility | DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.25 mg/ml | | form | A solid | | pka | 7.20±0.20(Predicted) |
| | Sappanone A Usage And Synthesis |
| Description | Sappanone A is a homoisoflavonoid with diverse biological activities that has been isolated from the aerial parts of C. pulcherrima, the heartwood of C. sappan, and the stems of H. campechianum. In vitro, sappanone A inhibits 76.2, 59.2, 37.4, and 35.4% of FGFR1, KDR, c-Met, and c-Kit kinase activity, respectively, when used at a concentration of 10 μM. It also inhibits influenza viral neuraminidase (NA) with IC50 values of 0.7, 1.1, and 1 μM for H1N1, H3N2, and H9N2 influenza viral NAs, respectively. Sappanone A has antibacterial activity against Gram-positive B. subtilis, B. sphaericus, and S. aureus as well as Gram-negative K. aerogenes and C. violaceum. It also inhibits the growth of A. niger and C. albicans fungi. Sapannone A inhibits LPS-induced inflammatory responses in vitro and in vivo, reducing nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E2 (PGE2; ) production in RAW264.7 cells as well as LPS-induced mortality in mice. It also attenuates airway inflammation and mucus hypersecretion via activation of the Nrf2 signaling pathway in a mouse model of ovalbumin-induced asthma. | | Uses | Sappanone A is a natural product flavonoid with some antioxidant properties that can be isolated from C. sappan. |
| | Sappanone A Preparation Products And Raw materials |
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